急性白血病患者血浆组织因子及组织因子途径抑制物的测定

目的 :观察急性白血病患者血浆TF ,TFPI的活性变化及其与凝血机能的关系。方法 :用发色底物法测定TF ,TFPI活性。结果 :急性白血病患者血浆TF活性高于正常对照组 (P <0 .0 1) ,TFPI活性低于对照组 (P <0 .0 1)。 7例初治患者化疗后血浆TF活性较化疗前下降 (P <0 .0 1) ,TFPI活性较化疗前升高 (P <0 .0 5 )。结论 :急性白血病患者凝血紊乱与血浆TF和TFPI活性改变有关。

Levels of plasma TF and TFPI acitivities in patients with acute leukemia

Objective: To investigate the changes of plasma tissue factor(TF) and tissue factor pathway inhibitor(TFPI) activities in the patients with acute leukemia. Methods: TF and TFPI activities were measured by using chromogenic assays. Results: Plasma TF activity in the patients with acute leukemia was higher and TFPI activity was lower than those in normal(P<0.01). In 7 patients who underwent the first chemotherapy, the plasma TF activity was decreased after chemotherapy(P<0.01), while TFPI activity increased(P<0.05). Conclusion: The unbalance between plasma TF and TFPI activities contributes to the coagulant disorders in acute leukemia.