| 星点设计-效应面法优化夏天无总生物碱微孔渗透泵片处方 |
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| 引用本文： | 李杰,尹蓉莉,李东芬,吕懿平,赵明琴,李开. 星点设计-效应面法优化夏天无总生物碱微孔渗透泵片处方[J]. 中国实验方剂学杂志, 2012, 18(16): 49-53 |
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| 作者姓名： | 李杰 尹蓉莉 李东芬 吕懿平 赵明琴 李开 |
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| 作者单位： | 成都中医药大学药学院,成都,611137 |
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| 摘 要： | 目的:应用星点设计-效应面法优化夏天无总生物碱微孔渗透泵片处方.方法:以NaCl用量、致孔剂含量、包衣增质量为自变量,药物累积释药量及累积释放量曲线的线性相关系数(r)为因变量,应用Design Expert对处方进行优化,并对优化处方进行验证.结果:最优处方为NaCl用量34 mg,致孔剂质量分数99％,包衣增质量4％；优化处方呈零级释放特性.结论:通过星点设计-效应面法成功建立了处方优化模型,实现了夏天无总生物碱微孔渗透泵片的处方筛选.
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| 关 键 词： | 夏天无 总生物碱 微孔渗透泵片 星点设计 效应面 |
| 收稿时间： | 2012-03-29 |
Optimization of Microporosity Osmotic Pump Tablet Prescription of Total Alkaloids from Corydalis decumbens by Central Composite Design-Response Surface Methodology |
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| LI Jie,YIN Rong-li,LI Dong-fen,LV Yi-ping,ZHAO Ming-qin and LI Kai. Optimization of Microporosity Osmotic Pump Tablet Prescription of Total Alkaloids from Corydalis decumbens by Central Composite Design-Response Surface Methodology[J]. China Journal of Experimental Traditional Medical Formulae, 2012, 18(16): 49-53 |
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| Authors: | LI Jie YIN Rong-li LI Dong-fen LV Yi-ping ZHAO Ming-qin LI Kai |
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| Affiliation: | College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China |
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| Abstract: | |
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| Keywords: | Corydalis decumbens total alkaloids microporosity osmotic pump tablet central composite design response surface |
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