益气养阴法对晚期肺癌患者化疗后消化道反应及生活质量的影响

目的:观察益气养阴法对晚期肺癌患者化疗后消化道反应及生活质量的影响.方法:选择住院治疗晚期肺癌患者85例,采用随机对照法分为治疗组(n=45)和对照组(n=40).分别采用化疗配合益气养阴法和单纯化疗,4周为1个周期,2个周期后比较两组治疗前后中医证候、KPS评分、体重、生活质量.结果:两组可改善肺癌咳嗽、血痰、胸痛、发热、气短乏力症状(P＜0.05),治疗组改善气促、乏力症状方面优于对照组(P＜0.05).治疗组在改善恶心呕吐、食欲不振、便秘症状,增加患者体重和KPS评分方面,均明显优于对照组(P＜0.05).两组均可提高患者的生活质量,治疗组在改善生理状况和功能状况方面优于对照组,毒副反应两组结果相当.结论:对于应用含顺铂化疗方案的晚期肺癌患者,运用益气养阴法为主的方药不仅可以改善肺癌症状,而且能更有效地减轻化疗引起的消化道反应,提高生活质量.

Effect of Supplementing Qi and Nourishing Yin on Gastrointestinal Reactions and Quality of Life in Patients with Advanced Lung Cancer after Chemotherapy

Objective: To observe the effect of supplementing qi and nourishing yin on gastrointestinal reactions and quality of life in patients with advanced lung cancer after chemotherapy. Method: Eighty-five patients with advanced lung cancer were randomly divided into treatment group (n=45)and control group(n=40). The treatment group was given remedy of supplementing qi and nourishing yin combined with chemotherapy. The control group was given chemotherapy. A treatment cycle was four weeks. The traditional Chinese medicine (TCM) clinical symptoms, KPS score, body weight, quality of life in each group before and after treatment were observed in two cycles. Result: In the two groups, the symptom scores were improved after the treatment cycle (P<0.05). The treatment group could relieve the lung cancer clinical syndromes including cough, bloody sputum, chest pain, shortness of breath and fatigue better than control group(P<0.05). The treatment group could significantly relieve syndromes of nausea and vomiting, loss of appetite, constipation, improving the quality of life and body weight comparing to control group(P<0.05). Compared with the control group, the physical condition and functional status of the patients in the treatment were better (P<0.05). As side effects and toxicity concerned, the results were similar in two groups. Conclusion: As for the advanced lung cancer patients of chemotherapy with cisplatin, the use of supplementing qi and nourishing yin decoction can not only improve the symptoms of lung cancer, but also effectively reduce gastrointestinal reactions induced by chemotherapy and improve patient's quality of life.