| 天疱疮抗体致棘刺松解量化研究 |
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| 引用本文： | 刁庆春,钟白玉,唐书谦,李渝. 天疱疮抗体致棘刺松解量化研究[J]. 临床皮肤科杂志, 2001, 30(3): 142-144 |
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| 作者姓名： | 刁庆春 钟白玉 唐书谦 李渝 |
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| 作者单位： | 1. 第三军医大学西南医院皮肤科,
2. 解放军 307医院皮肤科, |
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| 摘 要： | 观察1例寻常型天疱疮不同浓度天疱疮抗体（Pab)致表皮棘刺松解的作用,及对组织尿激酶型纤溶酶原（uPA)表达的影响。结果提示间接免疫荧光（IIF）检出Pab量接近Pab致棘刺松解量,IIF阴性可作为病情缓解的可靠指标,而直接免疫荧光（DIF）更适于作为活动性天疱疮的诊断指标。
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| 关 键 词： | 天疱疮 抗体 棘刺松解 量化研究 |
| 文章编号： | 1000-4963(2001)03-0142-03 |
| 修稿时间： | 2000-02-12 |
A quantity study of acantholysis caused by pemphigus antibody |
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| DIAO Qing-chun,LI Yu,ZHONG Bai-yu,TANG Shu-qian. A quantity study of acantholysis caused by pemphigus antibody[J]. Journal of Clinical Dermatology, 2001, 30(3): 142-144 |
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| Authors: | DIAO Qing-chun LI Yu ZHONG Bai-yu TANG Shu-qian |
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| Abstract: | In a pemphigus organ culture model, the different concentration of pemphigus antibodies(PAb) which cause acantholysis and influence the expression of urokinase plasminogen activator (uPA) was observed. The result has suggested that the concentration of PAb detected by indirect immunofluorescence(IIF) test is almost equal to the acantholytic level. The negative result of IIF can be used as the reliable marker of the remission. The direct immunofluorescence(DIF) test is more suitable for the diagnosis of active pemphigus. |
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| Keywords: | Pemphigus Antibody Acantholysis |
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