Graves病患者甲状腺和外周静脉血中甲状腺特异性抗体的对比研究

本文对比研究１１例Ｇｒａｖｅｓ病（ＧＤ）和９例非ＧＤ患者甲状腺静脉血（ＴＶＢ）和外周静脉血（ＰＶＢ）中甲状腺刺激抗体（ＴＳＡｂ）、甲状腺球蛋白抗体（ＴＧＡｂ）和甲状腺过氧化物酶抗体（ＴＰＯＡｂ）的活性和Ｔ３、Ｔ４浓度。结果显示：（１）抗体阳性的ＧＤ患者，其ＴＶＢ中ＴＳＡｂ、ＴＧＡｂ和ＴＰＯＡｂ水平均显著高于ＰＶＥ的，ＰＶＢ和ＴＶＢ的ＴＳＡｂ活性呈显著正相关，这提示甲状腺本身是甲状腺特异性抗体产生的主要部位；（２）ＧＤ组和非ＧＤ组ＴＶＢ和ＰＶＢ的血清Ｔ３、Ｔ４不形成浓度梯度；（３）ＴＳＡｂ、ＴＧＡｂ和ＴＰＯＡｂ活性及其在ＴＶＢ和ＰＶＢ之间的活性梯度，与ＴＶＢ和ＰＶＢ中Ｔ３、Ｔ４浓度均无相关关系。

Comparison Between Levels of Thyroid Autoantibodies in Thyroidal and Peripheral Venous Blood of Patients with Graves' Disease

In order to investigate the site of production of thyroid autoantibodies in Graves' disease,thyroid stimulating antibody(TSAb),thyroglobulin antibody (TGAb) and thyroid peroxidase antibody(TPOAb) levels in both thyroidal and. peripheral venous blood(TVB andPVB) were determined during operation in 11 patients with Graves' disease , 9 patients without Graves' disease. The levels of TSAb ,TGAb and TPOAb in TVB were significantly higher than those in PVB of patients with Graves' disease who were positive for these autoantibodies. No gradient of concentration for serum T_3 ,T_4 was found between TVB and PVB in patients with or without Graves' disease. There was no statistical correlation between TSAb,TGAb or TPOAb levels and serum T_3 or T_4 in TVB or PVB of patients with Graves' disease,however TSAb levels in PVB were markedly correlated with those in TVB. The results indicate that the thyroid gland of patients with Graves'disease is the site of production for thyroid autoantibodies.