| ISL-1在大鼠海马分布的免疫组织化学研究 |
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| 引用本文： | 陈彪 钟世镇. ISL-1在大鼠海马分布的免疫组织化学研究[J]. 神经解剖学杂志, 1998, 14(1): 78-80 |
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| 作者姓名： | 陈彪 钟世镇 |
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| 作者单位： | 解放军北京医学高等专科学校基础部!北京，100071，解放军北京医学高等专科学校基础部!北京，100071，第一军医大学解剖学教研室!广州，510515，军事医学科学院三所!北京，100850 |
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| 摘 要： | islet－1基因是同源框基因LIM家族的一员。LIM同源框基因在中枢神经系统中的作用引起了人们越来越多的关注。本文作者等采用免疫组织化学ABC法研究了同源框基因islet－1的表达产物（ISL－1）在大鼠海马中的分布，结果表明ISL－1广泛分布于成年大鼠海马各区的神经元内。鉴于同源框基因的表达产物主要为参与基因的表达调控，提示该基因与成年大鼠海马神经元的基因表达调控有着密切的关系。
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| 关 键 词： | 同源框基因 免疫组织化学 海马 大鼠 |
IMMUNOHISTOCHEMICAL STUDY OF ISL-1 IN RAT HIPPOCAMPUS |
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| Chen Biao, Zhou Changman, Zhong Shizhen, Fan Ming. IMMUNOHISTOCHEMICAL STUDY OF ISL-1 IN RAT HIPPOCAMPUS[J]. Chinese Journal of Neuroanatomy, 1998, 14(1): 78-80 |
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| Authors: | Chen Biao Zhou Changman Zhong Shizhen Fan Ming |
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| Abstract: | The gene islet-1 is a member of the LIM/homeobox gene family. Recently, researchers paid close attention to the effects of LIM homeobox genes in central nervous system. The distribution of the gene islet-l (ISL-1) in hippocampus of adult rat was studied with its specified antibody immunoh is tochemistry. There sultshowed that ISL-1 was mamly located in neuronal nucleus and widely distributed in every region of hippocampus of adult rat. In view that the homeobox gene product participated chiefly in control of gene expression, it is suggested that the gene islet-1 might play important roles in control of gene expression in neurons of adult rat hippocampus. |
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| Keywords: | homeobox gene immunohistochemistry hippocampus rat |
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