| AKT/PKB通路在非小细胞肺癌中作用的研究进展 |
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| 引用本文： | 蒲蓉,李为民.AKT/PKB通路在非小细胞肺癌中作用的研究进展[J].国际呼吸杂志,2009,29(8). |
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| 作者姓名： | 蒲蓉 李为民 |
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| 作者单位： | 四川大学华西医院呼吸内科,成都,610041 |
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| 摘 要： | AKT/~白激酶B(protein kinase B,PKB)是一种丝氨酸/苏氨酸蛋白激酶,传递生长因子等胞外刺激信号,参与调节细胞凋亡、增生、分化和代谢等一系列生理活动.目前在肿瘤的研究中发现AKT/PKB的激活与肿瘤的发生、发展以及肿瘤血管的形成都有密切的关系.本文就AKT/PKB通路在非小细胞肺癌中作用的研究进展进行综述.
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| 关 键 词： | 磷酸化 非小细胞肺癌 |
Research development of AKT/PKB pathway in non-small cell lung cancer |
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| PU Rong,LI Wei-min.Research development of AKT/PKB pathway in non-small cell lung cancer[J].International Journal of Respiration,2009,29(8). |
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| Authors: | PU Rong LI Wei-min |
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| Abstract: | AKT/protein kinase B(PKB)is a kind of serine/thyring kinases.It plays a role in the transportation of extracellular stimuli signal,such as growth factor,and participates in a series of physiological activities,such as cell apoptosis,proliferation,differation and metabolism.At present,manyresearches show AKT/PKB has close relationship with tumor genesis,development and angiogenesis.The article reviews the role of AKT/PKB pathway in non-small cell lung cancer. |
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| Keywords: | AKT/PKB |
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