Aplastic anemia following administration of a tumor necrosis factor-alpha inhibitor |
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| Authors: | Kuruvilla John Leitch Heather A Vickars Linda M Galbraith Paul F Li Charles H Al-Saab Saad Naiman Sheldon C |
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| Affiliation: | Division of Hematology, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada. |
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| Abstract: | Upregulation of tumor necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of several inflammatory conditions, including rheumatoid arthritis. Therapeutic agents such as antibodies or soluble TNF-alpha receptor analogs, which block TNF-alpha activity are a recent addition to the therapeutic armamentarium for the conditions. We describe a patient who developed aplastic anemia complicated by sepsis after receiving etanercept, a TNF-alpha receptor analog, for the treatment of rheumatoid arthritis. Pancytopenia resolved within 3 wk of discontinuing etanercept. To our knowledge, this is the first report of aplastic anemia associated with TNF-alpha blockade. |
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| Keywords: | aplastic anemia etanercept tumor necrosis factor-α inhibition |
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