Donor-Type Myelodysplastic Syndrome with t(2;3) and Monosomy 7 after Allogeneic Peripheral Blood Stem Cell Transplantation and Liver Transplantation in a Patient with Severe-Type Aplastic Anemia |
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Authors: | Satoshi Hashino Fumie Fujisawa Takeshi Kondo Masahiro Imamura Kazuya Sato Yoshihiro Torimoto Yutaka Kohgo Keisuke Kimura Hiroyuki Furukawa Satoru Todo Masahiro Asaka |
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Affiliation: | Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. |
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Abstract: | Secondary clonal hemaloiogical disease in donor cells has rarely been reported as a complication of allogeneic stem cell transplantation in hematological disease. We report a case of myelodysplastic syndrome that showed cytogenetic abnormalities of t(2;3) and monosomy 7, which developed 2 years after peripheral blood stem cell transplantation for aplastic anemia and 1 year after liver transplantation for drug-induced hepatic failure. This secondary malignancy of donor origin is most frequently seen in patients with leukemia. We suspect that the chromosomal abnormalities are related to hepatitis-associated aplastic anemia, administration of granulocyte colony-stimulating factor and erythropoietin for posttransplantion pancytopenia, and repeated infections after liver transplantation. |
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Keywords: | Myelodysplastic syndrome Transplantation Aplastic anemia |
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