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Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours |
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| Authors: | Kivelä Antti-J Kivelä Jyrki Saarnio Juha Parkkila Seppo |
| Institution: | 1. Department of Anatomy and Cell Biology, University of Oulu, Finland;Institute of Medical Technology,University of Tampere and Tampere University Hospital, Finland 2. Institute of Dentistry, University of Helsinki, Finland;Research Institute of Military Medicine, Central Military Hospital, Helsinki, Finland 3. Department of Surgery, University of Oulu, Finland 4. Institute of Medical Technology,University of Tampere and Tampere University Hospital, Finland;Department of Clinical Chemistry, University of Oulu, Finland |
| Abstract: | Carbonic anhydrases (CAs) catalyse the hydration of C02 to bicarbonate at physiological pH. This chemical interconversion is crucial since HCO3- is the substrate for several biosynthetic reactions. This review is focused on the distribution and role of CA isoenzymes in both normal and pathological gastrointestinal (GI) tract tissues. It has been known for many years that CAs are widely present in the GI tract and play important roles in several physiological functions such as production of saliva, gastric acid, bile, and pancreatic juice as well as in absorption of salt and water in intestine. New information suggests that these enzymes participate in several processes that were not envisioned earlier. Especially, the recent reports on plasma membrane-bound isoenzymes IX and XII have raised considerable interest since they were reported to participate in cancer invasion and spread. They are induced by tumour hypoxia and may also play a role in von Hippel-Lindau (VHL)-mediated carcinogenesis. |
| Keywords: | Gastrointestinal tract Gastrointestinal tumour Carbonic anhydrases |
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