| 微小RNA在糖尿病肾病发病机制中的研究进展 |
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| 引用本文： | 段英连,马婵娟. 微小RNA在糖尿病肾病发病机制中的研究进展[J]. 临床肾脏病杂志, 2021, 21(3): 243-248 |
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| 作者姓名： | 段英连 马婵娟 |
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| 作者单位： | 山西医科大学,太原030000;山西省人民医院肾内科,太原030053 |
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| 基金项目： | 国家自然科学基金青年科学基金项目(81300698);山西省自然科学基金应用基础研究计划项目(201901D111437)。 |
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| 摘 要： | 糖尿病肾病(diabetic kidney disease,DKD)是糖尿病(diabetes mellitus,DM)引起的微血管并发症之一,是DM患者预期寿命减少的主要原因.现已明确DKD发病机制与细胞外基质积累、氧化应激、炎症反应、自噬等有关.微小RNA(microRNA,miRNA)很稳定,可以在人的体液中检测...
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| 关 键 词： | 糖尿病肾病 微小RNA 发病机制 |
Research advances of miRNA in the pathogenesis of diabetic kidney disease |
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| Duan Ying-lian,Ma Chan-juan. Research advances of miRNA in the pathogenesis of diabetic kidney disease[J]. Journal Of Clinical Nephrology, 2021, 21(3): 243-248 |
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| Authors: | Duan Ying-lian Ma Chan-juan |
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| Affiliation: | (Shanxi Medical University,Taiyuan 030000,China;Department of Nephrology,Shanxi Provincial People's Hospital,Taiyuan 030053,China) |
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| Abstract: | As one of the microvascular complications caused by diabetes mellitus,diabetic kidney disease(DKD)is a major cause for shorter life expectancy of diabetes mellitus(DM)patients.It has been known that the pathogenesis of DKD is correlated with an accumulation of extracellular matrix,oxidative stress,inflammatory response and autophagy.And miRNA remains quite stable and it may be detected in human fluids.As a promising biomarker for kidneys,it has provided supplements for testing indicators of kidney disease.A better understanding the regulatory role of miRNAs in the pathogenesis of DKD shall be vital in the diagnosis and treatment of DKD.This review focused upon the correlation between miRNAs and the pathogenesis of DKD. |
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| Keywords: | Diabetic kidney disease MiRNA Pathogenesis |
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