| 慢性乙型肝炎患者抗病毒治疗过程中发生肝癌的风险预测模型 |
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| 引用本文： | 徐佰国,向慧玲,韩涛. 慢性乙型肝炎患者抗病毒治疗过程中发生肝癌的风险预测模型[J]. 临床肝胆病杂志, 2021, 37(2): 433-436 |
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| 作者姓名： | 徐佰国 向慧玲 韩涛 |
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| 作者单位： | 天津医科大学三中心临床学院消化(肝病)科;天津市重症疾病体外生命支持重点实验室;天津市人工细胞工程技术研究中心;天津市肝胆研究所,天津 300170;天津医科大学三中心临床学院消化(肝病)科;天津市重症疾病体外生命支持重点实验室;天津市人工细胞工程技术研究中心;天津市肝胆研究所,天津 300170;天津医科大学三中心临床学院消化(肝病)科;天津市重症疾病体外生命支持重点实验室;天津市人工细胞工程技术研究中心;天津市肝胆研究所,天津 300170 |
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| 基金项目： | 天津市卫生行业重点攻关项目(16KG152)。 |
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| 摘 要： | HBV感染是肝硬化和肝癌的主要病因之一。抗病毒药物的使用明显降低了慢性乙型肝炎患者肝癌的发生风险,但部分长期服用抗病毒药物患者,最终仍发生肝癌。因此,有必要对此类患者发生肝癌的风险进行早期识别和预测。当前根据肝硬化、年龄、性别、肝硬度、病毒学、血清学指标、饮酒情况、糖尿病病史等危险因素,形成了一些慢性乙型肝炎患者抗病毒治疗过程中发生肝癌的风险预测模型,这些预测模型包括mREACH-B、PAGE-B、mPAGE-B、APA-B、CAMD、AASL、REAL-B等。综述了慢性乙型肝炎患者抗病毒治疗过程中发生肝癌的风险预测模型研究进展。
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| 关 键 词： | 乙型肝炎 慢性 肝肿瘤 危险因素 |
Advances in the models for predicting the risk of liver cancer during antiviral therapy in patients with chronic hepatitis B |
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| XU Baiguo,XIANG Huiling,HAN Tao. Advances in the models for predicting the risk of liver cancer during antiviral therapy in patients with chronic hepatitis B[J]. Chinese Journal of Clinical Hepatology, 2021, 37(2): 433-436 |
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| Authors: | XU Baiguo XIANG Huiling HAN Tao |
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| Affiliation: | (Department of Hepatology and Gastroenterology,The Third Central Clinical College of Tianjin Medical University/Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases/Artificial Cell Engineering Technology Research Center/Tianjin Institute of Hepatobiliary Disease,Tianjin 300170,China) |
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| Abstract: | Hepatitis B virus infection is one of the primary causes of liver cirrhosis and liver cancer.The use of antiviral drugs significantly reduces the risk of liver cancer in patients with chronic hepatitis B(CHB),but some of the patients who receive antiviral drugs for a long time still develop liver cancer.Therefore,it is necessary to early identify and predict the risk of liver cancer in such patients.Currently,several models for predicting the risk of liver cancer during antiviral therapy in CHB patients have been developed based on the risk factors such as liver cirrhosis,age,sex,liver stiffness,virology,serological markers,alcohol consumption,and history of diabetes,including REACH-B,PAGE-B,mPAGE-B,APA-B,CAMD,AASL,and REAL-B.This article reviews the research advances in the models for predicting the risk of liver cancer during antiviral therapy in CHB patients. |
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| Keywords: | Hepatitis B,Chronic Liver Neoplasms Risk Factors |
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