血清淀粉样蛋白A、高敏C反应蛋白、一氧化氮与稳定型冠心病不良心血管事件的关系

目的 探讨血清淀粉样蛋白A、高敏C反应蛋白、一氧化氮水平与稳定型冠心病不良心血管事件的关系.方法 回顾性选择稳定型冠心病患者161例,并根据1年的随访结果分为A组(发生不良心血管事件,78例)和B组(未发生不良心血管事件,83例),收集分析患者临床资料,分析稳定型冠心病发生不良心血管事件危险因素,观察血清淀粉样蛋白A、...

Relationship between serum amyloid A,high sensitive C-reactive protein,nitric oxide and adverse cardiovascular events in patients with stable coronary heart disease

Objective To investigate the relationship between serum amyloid A(SAA),high-sensitivity C-reactive protein(hs-CRP),nitric oxide(NO)and adverse cardiovascular events(ACE)in patients with stable coronary heart disease(CHD).Methods 161 patients with stable CHD were selected retrospectively,and were divided into group A(78 cases with ACE)and group B(83 cases without adverse cardiovascular events)based on one-year follow-up results.The clinical data of the patients were collected,the risk factors of ACE in stable CHD were analyzed,and the predictive value of SAA,hs-CRP and NO for ACE in stable CHD was observed.Results The incidence of diabetes and hypertension in group A was significantly higher than that in group B(P<0.05).SAA and hs-CRP in group A were significantly higher than those in group B,and NO was lower than that in group B(P<0.05).Logistic regression analysis showed that diabetes mellitus,hypertension,SAA,hs-CRP,NO were the risk factors of ACE in stable CHD.ROC curve showing the AUC of SAA,hs-CRP and NO in the diagnosis of ACE in patients with stable CHD was 0.603,0.633 and 0.706 respectively,the specificity was 0.634,0.651 and 0.680 respectively,the sensitivity was 0.673,0.665 and 0.673 respectively,the AUC of the three combined diagnosis of cardiovascular adverse events in patients with stable CHD was 0.744,the specificity was 0.716 and the sensitivity was 0.773.Conclusion High expression of SAA,high expression of hs-CRP and low expression of NO are the risk factors of ACE in patients with stable CHD,and the combination of the three factors has a high clinical value in predicting ACE in patients with stable CHD.