HBV感染肾小管细胞机制的研究进展

肾脏具备HBV感染肝细胞的关键因素,HBV相关肾小球肾炎(HBV-GN)的发病机制尚未完全明确,近年来HBV直接损伤肾小管的机制越来越受到重视。HBV可以通过调节细胞周期、激活NF-κB等相关信号转导通路诱导肾小管细胞凋亡,导致HBV-GN进展。目前在临床上尚无作用靶点位于肾脏治疗HBV-GN的药物。将HBV感染细胞的关键因素和HBV损伤肾小管细胞研究进展总结如下,阐述HBV直接感染肾小管细胞的可能机制,为HBV-GN的治疗提供新思路。

Research advances in infection of renal tubular cells by hepatitis B virus

The kidney plays a key role in hepatitis B virus(HBV)infection of liver cells.The pathogenesis of HBV-associated glomerulonephritis(HBV-GN)remains unclear,and the mechanism of HBV directly causing the injury of renal tubules has been taken seriously in recent years.HBV can induce the apoptosis of renal tubular cells by regulating cell cycle and activating related signaling pathways including NF-κB and thus lead to the progression of HBV-GN.At present,there are still no drugs targeting the kidney in the treatment of HBV-GN.This article summarizes the research advances in the key factors for HBV infection of cells and the injury of renal tubular cells caused by HBV and elaborates on the possible mechanism of direct infection of renal tubular cells by HBV,so as to provide new ideas for the treatment of HBV-GN.