剪切波弹性成像诊断甲状腺相关性眼病眼外肌病变的价值

目的 应用剪切波弹性成像(SWE)评估甲状腺相关性眼病眼外肌病变(TAO)中4条眼外肌厚径及杨氏模量平均值(Emean)变化,探讨其对TAO的诊断价值.方法 随机收集在我院内分泌科住院的TAO患者60例,其中TAO水肿期患者38例(A组),TAO纤维化期患者22例(B组),另选同期年龄、性别与之相匹配的健康志愿者50例...

Application of shear wave elastography in extraocular myopathies of thyroidophthalmopathy

Objective To evaluate the thickness and mean Young’s modulus(Emean)of four extraocular muscles in thyroid associated ophthalmopathy(TAO)by shear wave elastography(SWE),and to explore SWE diagnostic value for TAO.Methods A random collection of 60 TAO patients hospitalized in the endocrinology department of our hospital were divided into two subgroups:38 patients in TAO edema stage(group A)and 22 patients in TAO fibrosis stage(group B),50 healthy volunteers matching age and sex during the same period were selected as the control group.High-frequency ultrasound was used to measure the thickness of extraocular muscles,and SWE was used to measure Emean of extraocular muscles,the difference of above parameters among three groups were compared.The ROC curve was drawn,and the diagnostic efficiency of Tao was analyzed.Results The thickness and Emean value of extraocular muscles in the group A and group B were higher than those in the control group(both P<0.05).The Emean values of the four extraocular muscles in the control group,group A,and group B gradually increased(P<0.05),and there was no significant difference in thickness between the group A and group B.The Emean cut-off value of superior,inferior,lateral and medial rectus for diagnosing TAO were 9.85 kPa,9.65 kPa,9.85 kPa,9.65 kPa,respectively,the sensitivity were 86%,78%,82%,80%,and the specificity were 90%,95%,95%,98%.Conclusion SWE can quantitatively assess the elasticity of extraocular muscles,which provide a reference for clinical diagnosis of extraocular muscle diseases in TAO.