大豆蛋白在慢性肾脏病中作用的Meta分析

目的 评价大豆蛋白对慢性肾脏病(chronic kidney disease,CKD)的影响,为大豆蛋白在CKD患者饮食结构中的重要性提供参考依据.方法 检索PubMed,Embase,Cochrane图书馆,中国知网,中国科学技术杂志,万方中文数据库和中国生物医学(CBM)数据库(建库时间至2020年6月30日).文...

Meta analysis of the role of soy protein in chronic kidney disease

Objective To evaluate the impact of soy protein on chronic kidney disease(CKD)and provide references for the importance of adding soy protein in a CKD diet.Methods The databases of PubMed,Embase,Cochrane Library,National Knowledge Infrastructure of China,Chinese Journal of Science&Technology,WanFang Data Chinese Edition and China Biomedicine(CBM)were searched since their inceptions until June 30,2020.After literature screening,quality evaluation was performed and Rev Man5.3 software utilized for Meta-analysis.Results Nine articles involving a total of 429 subjects from 5 countries were included.Meta-analysis indicated that soy protein diet could lower the levels of serum creatinine(Scr)SMD=-0.33,95%CI(-0.54,-0.13),P=0.001],blood urea nitrogen(BUN)SMD=-0.45,95%CI(-0.89,-0.01),P=0.05]and low-density lipoprotein-cholesterol(LDL-C)SMD=-0.79,95%CI(-1.10,-0.47),P<0.001]in CKD patients.The levels decreased markedly as compared with control group and there were statistical differences(P<0.05).And the effects on glomerular filtration rate(GFR),proteinuria and serum phosphorus were not significantly different from those of control group.Conclusion Soy protein may reduce the levels of Scr,BUN and LDL-C in CKD patients.Based upon a low quality of literature reports and a protracted disease course of CKD,some conclusions should be further verified by larger studies with longer treatment courses.