血清高迁移率族蛋白B1、淀粉酶样蛋白A水平变化在新生儿感染性休克中的临床意义

目的 探讨新生儿感染性休克患儿血清高迁移率族蛋白B1(HMGB1)、淀粉酶样蛋白A(SAA)水平的临床意义。方法 2018年8月至2020年8月于我院出生并诊治的新生儿感染性休克患儿87例以及于我院出生并诊治的普通感染组新生儿50例进行对照研究,通过酶联免疫吸附实验测定两组新生儿血清HMGB和SAA水平。结果 新生儿感染性休克组患儿血清HMGB1和SAA水平均要显著高于普通感染组患儿(P<0.05);新生儿感染性休克患儿中,生存组患儿血清HMGB1和SAA水平均要明显低于死亡组患儿(P<0.05),血清HMGB1水平与血清SAA水平呈显著正相关(r=0.708,P<0.05)。结论 新生儿感染性休克患儿血清HMGB1和SAA水平越高,患儿预后越差,可作为新生儿感染性休克病情严重程度和预后的重要指标。

Clinical significance of serum high mobility group protein B1 and serum amyloid aprotein levels in newborn with septic shock

Objective To investigate the clinical significance of serum high mobility group protein B1 (HMGB1) and serum amyloid aprotein (SAA) levels in newborns with septic shock. Methods The serum HMGB and SAA levels of newborns were measured by enzyme-linked immunosorbent assay between shock group (n=87, cases with septic shock ) and normal group (n=50, cases with common infection), those cases were all born and treated in our hospital from August 2018 to August 2020. Results The serum HMGB1 and SAA levels of newborn in shock group were significantly higher than those in normal group (P<0.05); among neonatal septic shock children, the serum HMGB1 and SAA levels of surviving newborn were significantly lower than those of dead newborn (P<0.05). The serm HMGB1 level was significant positively correlation with the serum SAA level (r=0.708, P<0.05). Conclusion The higher the serum HMGB1 and SAA, the worse the prognosis of neonatal septic shock. The two items can be used as important indicators of the severity and prognosis of neonatal septic shock.