新疆地区老年非小细胞肺癌患者化疗前 轻度肺功能降低调查及个体化有氧运动干预效果分析

目的分析个体化有氧运动的干预效果。方法收集246例接受化疗的新疆地区老年NSCLC患者作为研究对象,通过肺功能检查调查化疗前的肺功能情况。随后将132例伴有轻度肺功能降低患者随机分为对照组和观察组,每组各66例。对照组给予常规呼吸训练干预,观察组给予个体化有氧运动干预。采用欧洲癌症研究和治疗协作组编制的癌症病人生活质量评估表(EORTCQLQ-C30)评价患者生活质量。比较两组患者心肺并发症(PCC)发生率及干预前后的肺功能指标和生活质量评分。结果:246例NSCLC患者中,轻度肺功能降低发生率为53.6%。与对照组相比,观察组PCC发生率降低(33.3%与51.5%,P<0.05)。且观察组患者干预后FEV 1、FVC、MVV等肺功能指标水平高于对照组,躯体功能、角色功能、情绪功能、认知功能及社会功能等生活质量评分高于对照组,组间比较都有统计学差异(P均<0.05)。结论新疆地区老年NSCLC患者轻度肺功能降低比例大,对此进行个体化有氧运动干预能够降低化疗中PCC发生率,并且能够改善肺功能和生活质量。

Investigation of mild reduced pulmonary function before chemotherapy in Xinjiang elderly patients with non-small cell lung cancer and analysis of intervention effect of individual aerobic exercise

Objective To investigate reduced pulmonary function before chemotherapy in Xinjiang elderly patients with non-small cell lung cancer(NSCLC)and to analyze the intervention effect of individual aerobic exercise.Methods 246 cases of Xinjiang elderly patients with NSCLC who received chemotherapy were collected as research objects,and status of pulmonary function before chemotherapy were investigated by pulmonary function examination.Afterwards,those 132 patients who complicated with mild reduced pulmonary function were randomly divided into the control group and the observation group with 66 cases in each group.The control group was given intervention of conventional respiratory training,while the observation group was given intervention of individual aerobic exercise.EORTCQLQ-C30 was employed to assess quality of life.The incidence of postoperative cardiopulmonary complication(PCC)and indices of pulmonary function,scores of quality of life before and after intervention were compared between the two groups.Results In those 246 patients with NSCLC,the incidence of mild reduced pulmonary function was 53.6%.In comparison with the control group,the incidence of PCC in the observation group was lower(33.3%vs 51.5%,P<0.05).And after intervention,the levels of indices of pulmonary function of FEV 1,FVC,MVV and scores of physical function,role function,emotional function,cognitive function,social function in the observation group were statistically higher than those in the control group(all P<0.05).Conclusion Xinjiang elderly patients with NSCLC has a large proportion of those with mild reduced pulmonary function,and individual aerobic exercise intervention can reduce incidence of PCC,and improve pulmonary function and quality of life.