血清CA125、SCCA在肺结核与肺癌患者中的表达对比分析

目的 探讨血清糖类抗原125(Carbohydrate antigen 125,CA125)、鳞状细胞相关癌抗原(Squamous cell associated oncoantigen,SCCA)在肺结核与肺癌患者表达含量,为临床辅助鉴别诊断肺结核与肺癌提供实验依据.方法 选取2019年6月至2019年12月于该院确...

Comparative analysis of serum CA125 and SCCA expression between pulmonary tuberculosis and lung cancer patients

Objective To investigate the expression levels of serum CA125 and SCCA in patients with pulmonary tuberculosis and lung cancer,so as to provide experimental basis for clinical differential diagnosis of pulmonary tuberculosis and lung cancer.Methods It was selected a total of 87 patients with pulmonary tuberculosis(the pulmonary tuberculosis group)and 79 patients with lung cancer(the lung cancer group)diagnosed in our hospital from June 2019 to December 2019,and 50 healthy people were collected(the control group).The contents of serum CA125 and SCCA in the three groups were detected by electrochemiluminescence method.Results The content of CA125 in the pulmonary tuberculosis group(75.54±26.23U/mL)was significantly higher than that in the lung cancer group(46.08±13.76U/mL),which was significantly higher than that in the control group(11.52±5.92U/mL)(P<0.05).The content of SCCA in the lung cancer group(2.68±1.30ng/mL)was significantly higher than that in the pulmonary tuberculosis group(1.07±0.68ng/mL)and the control group(1.03±0.45ng/mL)(P<0.05).The levels of CA125 and SCCA in stageⅣlung cancer[CA125(50.96±14.52U/mL),SCCA(3.18±1.18ng/mL)]were significantly higher than those in stageⅢ[CA125(40.54±10.54U/mL),SCCA(2.11±1.20ng/mL)].The CA125 content of the adenocarcinoma group(50.00±14.58U/mL)was significantly higher than that of the squamous cell carcinoma group(42.79±12.27ng/mL)(P<0.05).The SCCA content of the squamous cell carcinoma group(3.08±1.18ng/mL)was significantly higher than that of the adenocarcinoma group(2.20±1.30 ng/mL)(P<0.05).Conclusion The combined detection of serum CA125 and SCCA has a certain clinical value in the differential diagnosis of pulmonary tuberculosis and lung cancer,and it has a certain reference value for the staging and classification of lung cancer.