超声诊疗一体机VINNO 70空化调控功能及声学测量的研究

目的探索新型超声诊疗一体机VINNO 70的空化调控功能及其测量相关声学参数的情况,研究自适应可变焦域技术靶向击破微泡的能力。方法利用薄膜水听器法测量X4-12L线阵探头和S1-8C凸阵探头对超声频率(f)、脉冲宽度(PL)、脉冲重复频率(PRF)的实测值,验证其与仪器显示值的一致性;重点测量探头距换能器表面2 cm和5 cm处感兴趣区内的峰值负压(PNP),计算对应的机械指数(MI),并与仪器显示值比较。分析自适应可变焦域技术靶向击破微泡的能力,记录微泡击破程度。结果X4-12L线阵探头与S1-8C凸阵探头的f、PL及PRF实测值与仪器显示值均一致。MI实测值与仪器显示值有较大差距(58%~267%),且f与测量距离均可以影响MI值。自适应可变焦域技术具有明显的超声弱聚焦性能,感兴趣区内微泡击破明显。结论超声诊疗一体机VINNO 70能准确调控多个空化相关参数;自适应可变焦域技术可靶向击破感兴趣区内微泡。MI实测值与显示值差别较大,治疗时应以实测值为准。

Research on cavitation modulation and acoustic measurement of VINNO 70 integrated ultrasound theranostic system

Objectives To investigate the cavitation modulation of VINNO 70 integrated ultrasound theranostic system and its acoustic parameters measurement,as well as the adaptive variable focus technique for targeted microbubble destruction.Methods The frequency(f),pulse length(PL),pulse repetition frequency(PRF)were measured by thin film hydrophone method to verify their consistency with the values displayed by the instrument.Similarly,the peak negative pressure(PNP)in the region of interest(ROI)2 cm and 5 cm away from the transducer surface were emphatically measured to calculate the corresponding mechanical index(MI),and they were compared with the values displayed by instrument.Microbubble destruction was recorded to analyze the adaptive variable focus technique.Results The values of f,PL and PRF of linear array probe X4-12L and convex array probe S1-8C were consistent with those displayed by the instrument.There was obvious difference between MI and the value displayed by the instrument(58%~267%),and MI was affected by f and the distance to the transducer.The adaptive variable focus technique had weakly focusing performance,and the microbubble in ROI was obviously broken.Conclusion VINNO 70 integrated ultrasound theranostic system can accurately regulate several cavitation related parameters,and the adaptive variable focus technique can target and break the microbubbles in ROI.Due to the difference between the measured value and the displayed value of MI,the measured value should be prevail considered during treatment.