孕激素类药物对妊娠期糖尿病的影响

孕激素类药物在临床应用非常广泛,非妊娠期可用于避孕、治疗子宫内膜异位症、调理月经等妇科疾病,妊娠期使用主要用于黄体支持治疗、预防和治疗先兆流产以及预防和治疗早产。孕激素在我国应用于孕早期保胎非常普遍且呈滥用趋势,近年有研究发现孕激素在孕期的使用可能导致妊娠期糖尿病的发生。本文从孕激素的分类、孕激素在妊娠期的使用与妊娠期糖尿病的相关性及孕激素导致妊娠期糖尿病发生的可能机制等方面对孕激素在妊娠期的使用对妊娠期糖尿病的影响做一综述,为临床在妊娠期合理使用孕激素类药物提供参考。

Effect of progesterone drugs on gestational diabetes mellitus

Progesterone drugs are widely used in clinical practice.They can be used for contraception,regulation of menstruation and treatment of endometriosis and other gynecological diseases during non-pregnancy period.They are mainly used for luteal support treatment and prevention and treatment of threatened abortion and premature birth during pregnancy.Progesterone is widely used in early pregnancy to protect the fetus in our country,which shows an abuse trend.In recent years,studies have revealed that the use of progesterone during pregnancy may lead to gestational diabetes mellitus.This paper reviews the effect of progesterone used during pregnancy on gestational diabetes mellitus from perspectives such as the classification of progesterone,the correlation between the use of progesterone during pregnancy and gestational diabetes mellitus,and the possible mechanisms of progesterone leading to gestational diabetes mellitus.It is expected to provide a clinical reference for the rational use of progesterone drugs in pregnancy.