诱导化疗+辅助化疗分别联合同步调强放化疗和调强放疗在治疗局部晚期鼻咽癌患者中的疗效比较

目的 探讨诱导化疗+同步调强放化疗+辅助化疗与诱导化疗+调强放疗+辅助化疗在局部晚期鼻咽癌中的疗效。方法 选择我院2018 年1～12 月进行治疗的60 例局部晚期鼻咽癌患者纳入本研究。按照随机数字表法分为两组,每组各30 例。A 组行诱导化疗+同步调强放化疗+辅助化疗,B 组行诱导化疗+调强放疗+辅助化疗。所有患者均获得18 个月随访,比较两组临床疗效、不良反应发生情况、随访期间生存和复发转移情况。结果 观察组和对照组RR 相同,组间比较差异无统计学意义（P＞0.05）;A 组患者骨髓抑制（60.00%）、胃肠道反应发生率（50.00%）均高于B 组的骨髓抑制（33.33%）、胃肠道反应发生率（23.33%）,差异有统计学意义（P＜0.05）;A 组口腔黏膜反应发生率为43.33%、皮肤损害发生率为16.67%,B 组口腔黏膜反应发生率为40.00%、皮肤损害发生率为13.33%,组间比较差异无统计学意义（P＞0.05）。两组生存率、局部复发率、远处转移率比较,差异无统计学意义（P＞0.05）。结论 诱导化疗+同步调强放化疗+辅助化疗与诱导化疗+调强放疗+辅助化疗治疗局部晚期鼻咽癌疗效相似,但诱导化疗加调强放疗加辅助化疗不良反应更少。

Comparison of therapeutic efficacy of induction chemotherapy plus adjuvant chemotherapy respectively combined with synchronous intensity modulated radiotherapy and chemotherapy plus intensity modulated radiotherapy in the treatment of patients with topically advanced nasopharyngeal carcinoma

Objective To explore the therapeutic efficacy of induction chemotherapy plus synchronous intensity modulated radiotherapy and chemotherapy plus adjuvant chemotherapy and induction chemotherapy plus intensity-modulated radiotherapy plus adjuvant chemotherapy in topically advanced nasopharyngeal carcinoma(NPC).Methods 60 patients with topically advanced NPC admitted to our hospital from January 2018 to December 2018 were selected and included in this research.According to the random number table method,they were divided into group A(n=30) and group B(n=30).Group A was given induction chemotherapy plus synchronous intensity modulated radiotherapy and chemotherapy plus adjuvant chemotherapy,while group B was given induction chemotherapy plus intensity modulated radiotherapy plus adjuvant chemotherapy.All patients were followed up for 18 months.The clinical efficacy,adverse reactions(ADRs),survival and relapse and metastasis during the follow-up were compared between the two groups.Results The RR rates of the observation group and the control group were the same,but there was no statistically significant difference between the two groups(P>0.05).The incidence of bone marrow suppression(60.00%) and gastrointestinal reaction(50.00%)in group A were all higher than the incidence of bone marrow suppression(33.33%) and gastrointestinal reaction(23.33%) in group B respectively,with statistically significant difference between groups(P<0.05).The incidence of oral mucosa reaction and skin damage in group A was 43.33% and 16.67%,while those in group B was 40.00% and 13.33% respectively,with no statistically significant differences between the two groups(P>0.05).There were no statistically significant differences in the survival rate,topical relapse rate and distant metastasis rate between the two groups(P>0.05).Conclusion Induction chemotherapy plus synchronous intensity modulated radiotherapy and chemotherapy plus adjuvant chemotherapy are similar to induction chemotherapy plus intensity modulated radiotherapy plus adjuvant chemotherapy for topically advanced NPC,but the ADRs of induction chemotherapy plus intensity-modulated radiotherapy plus adjuvant chemotherapy are less.