早发与晚发冠心病患者临床及冠状动脉病变特点的性别差异分析

目的:探讨早发与晚发冠心病患者临床及冠状动脉(冠脉)病变特点的性别差异.方法:收集2016年1月—2017年2月于我院心内科经冠脉造影(CAG)检查明确冠心病诊断的692例患者一般和临床资料,根据NECP-ATP Ⅲ规定将所纳入患者分为早发冠心病组(男性110例、女性83例)与晚发冠心病组(男性298例、女性201例)...

Sex differences of clinical and coronary artery features in patients with premature and mature coronary heart disease

Objective:To investigate sex differences of clinical and coronary artery features in patients with premature coronary artery disease(CHD)and mature CHD.Methods:The general and clinical data of 692 patients diagnosed with CHD by coronary angiography(CAG)from January 2016 to February 2017 in our hospital were collected.According to the NECP-ATPⅢregulations,all included patients were divided into premature CHD group(110 males and 83 females)and mature CHD group(298 males and 201 females).Sex differences in clinical and coronary artery features in the two groups were compared.Results:In the premature CHD group,compared with female patients,male patients showed higher incidences of smoking,drinking,family history of CHD,family history of hypertension,right coronary artery(RCA)disease and ST elevation myocardial infarction(STEMI),as well as higher levels of serum uric acid(UA),homocysteine(HCY);while showed lower proportions for combining hypertension,single vessel disease and stable angina pectoris(SAP),and lower levels of serum high-density lipoprotein cholesterol(HDL-C),apolipoprotein A and B,APOA/APOB(all P<0.05).In the mature CHD group,compared with female patients,male patients showed higher rates of smoking,drinking and STEMI,and higher serum UA,HCY levels;while showed lower ratios for combining hypertension and SAP,and lower serum levels of TC,HDL-C,APOA,APOA/APOB,PLT(all P<0.05).Compared with female patients in the mature CHD group,female patients in the premature CHD group showed higher proportions of single vessel disease and serum levels of TC,while showed lower rates of three vessel disease,RCA disease and serum levels of UA and HCY(all P<0.05).Compared with male patients in the mature CHD group,male patients in the premature CHD group showed higher rates of smoking,drinking,family history of CHD,family history of hypertension,double vessel disease,STEMI,and higher levels of BMI,TC,LDL-C,TG and PLT;while showed lower proportionds of hypertension and levels of HDL-C,APOA/APOB(all P<0.05).Conclusion:Smoking,drinking,high serum levels of UA and HCY are the main risk factors for male patients with CHD,and hypertension is the main risk factor for female patients with CHD.Moreover,high serum levels of TC,TG,LDL-C,PLT and BMI are related to the early occurrence of CHD in men,and the high TC serum level is related to the early occurrence of CHD in women.