大学生血尿酸与儿茶酚胺的相关性

目的研究大学生血尿酸(SUA)水平与儿茶酚胺及血压的相关性。方法用R语言分层随机抽样法自参与血压调查的5185名大学生中抽取285人,根据其血尿酸水平分为两组(非高尿酸血症组177例,高尿酸血症组108例),检测血儿茶酚胺、生化等指标并进行组间比较,分析SUA与血肾上腺素(E)、去甲肾上腺素(NE)、多巴胺(DA)、收缩压(SBP)、舒张压(DBP)、心率(HR)、体重指数(BMI)、空腹血糖(FBG)、血肌酐(SCr)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的相关性。结果女生高尿酸血症组血E高于非高尿酸血症组(P<0.05)。大学生人群高尿酸血症组SBP、DBP、BMI、SCr、SUA、TC、TG、LDL-C均高于非高尿酸血症组,HDL-C低于非高尿酸血症组(均P<0.05)。在女生中,SUA与E呈正相关(P<0.05)。所有入组者SUA水平与SBP、DBP、BMI、SCr、TG、LDL-C呈正相关(均P<0.05),与HDL-C呈负相关(P<0.05)。结论大学生高血压、肥胖、血脂异常、SCr升高与高尿酸血症的发生密切相关;大学生血浆E水平升高与高尿酸血症的发生有关,女生中血E与SUA的相关性较强。

Correlation between serum uric acid and catecholamines in college students

Objective To study the correlation between serum uric acid(SUA) level and catecholamines, blood pressure in college students. Methods A total of 285 from 5 185 college students who participated in the blood pressure survey were selected by using R language stratified random sampling method. According to SUA level, college students were divided into non-hyperuricemia group (177 cases) and hyperuricemia group (108 cases). The plasma catecholamine, biochemical and other indicators were tested and compared between two groups. The correlation was analyzed between SUA and plasma epinephrine(E), norepinephrine(NE), dopamine(DA), systolic blood pressure(SBP), diastolic blood pressures(DBP), heart rate(HR), body mass index(BMI), fasting blood glucose(FBG), serum creatinine(SCr), total cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol(HDL-C), and low-density lipoprotein cholesterol(LDL-C). Results In female college students, the plasma E in hyperuricemia group was higher than that in non-hyperuricemia group (P<0.05). In the college students, SBP, DBP, BMI, SCr, SUA, TC, TG, LDL-C in hyperuricemia group were higher than those in non-hyperuricemia group, but HDL-C was lower than that in non-hyperuricemia group (all P<0.05). SUA was positively correlated with plasma E in female college students (P<0.05). The SUA level of all participants was positively correlated with SBP, DBP, BMI, SCr, TG, and LDL-C (all P<0.05), but negatively correlated with HDL-C (P<0.05). Conclusion In the college students, hyperuricemia is closely related with hypertension, obesity, dyslipidemia, and elevated SCr, the higher plasma E level and the greater hyperuricemia risk. The correlation is the strongest between the plasma E and SUA in female college students.