Abstract: | Autophagy is a subcellular process that plays an important role in the process of lysosomal degradation of protein-damaged organelles,such as mitochondria.It is essential for the regulation of functions of protein and mitochondria and the maintenance of cellular homeostasis.The disorder of autophagy is related to many diseases,such as atherosclerosis.Recent studies have shown that autophagy defects exist during the progression of atherosclerosis,regardless of the presence of autophagy stimulating factors(such as reactive oxygen species,oxidized lipids and cytokines)in atherosclerotic plaques.This review focuses on the causes and consequences of autophagy defects in atherosclerosis,especially the impact on macrophages,vascular smooth muscle cells and endothelial cells,which may be of great significance for the treatment of autophagy targets for atherosclerosis. |