慢性阻塞性肺疾病频发加重表型患者危险因素分析

目的 分析导致慢性阻塞性肺疾病频发急性加重表型患者,频发加重的可能危险因素.方法收集2016年01月至2017年01月在上海交通大学医学院附属新华医院崇明分院呼吸科住院患者中被诊断为慢阻肺急性加重期的患者,根据患者急性加重发作频率,纳入51例频发急性加重表型患者并随访1年,观察1年内再次频发加重的患者比例及临床特征,采...

Investigation on related risk factors of frequent exacerbation phenotype of chronic obstructive pulmonary disease

Objective To analyze the risk factors related to the frequent acute exacerbation phenotype of COPD patients.Methods Patients hospitalized in respiratory department of Chongming branch of Xinhua hospital affiliated to Shanghai Jiaotong university school of medicine were collected according to their diagnosis of AECOPD from January 2016 to January 2017.Based on the frequency of acute exacerbation of COPD during last year,51 patients were selected and then followed up for 1 year.The logistic regression analysis was used to evaluate possible risk factors related to frequent exacerbation.Results The results of univariate logistic regression analysis showed that advanced age(≥77 years old),male,current smoking,CAT score≥14 and FEV 1pred<50%were the risk factors of AECOPD,and the results of multivariate logistic regression analysis indicated that independent risk factors for future frequent exacerbation included a higher CAT score(CAT score≥14),and more severe airflow obstruction(FEV 1pred<50%).Conclusion FEV 1pred<50%and CAT score≥14 are the two independent risk factors of acute exacerbation in patients with COPD.