| 胆汁酸-法尼醇核受体R-肠道微生态轴在肝衰竭发生及肝再生中的作用机制 |
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| 引用本文： | 陈研焰,蓝艳梅,王明刚,毛德文. 胆汁酸-法尼醇核受体R-肠道微生态轴在肝衰竭发生及肝再生中的作用机制[J]. 临床肝胆病杂志, 2021, 37(2): 480-484 |
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| 作者姓名： | 陈研焰 蓝艳梅 王明刚 毛德文 |
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| 作者单位： | 湖南中医药高等专科学校基础医学部,湖南株洲412000;广西中医药大学第一附属医院 科研部,南宁530023;广西中医药大学第一附属医院肝病科,南宁530023 |
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| 基金项目： | 国家自然科学基金(81960841,81774236,81704021,81760844);广西自然科学基金创新研究团队项目(2018GXNSFGA281002);广西自然科学基金(2017GXNSFBA198200,2018GXNSFAA281047);广西高校中青年教师基础能力提升项目(2019KY0318,XP019012)。 |
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| 摘 要： | 肝衰竭是常见的内科危重症,短时间内肝细胞大面积坏死而超过肝细胞再生能力导致该病病死率极高,促进有效肝再生是拮抗肝衰竭的关键。近年来发现胆汁酸、法尼醇核受体R、肠道微生态在肝衰竭和肝再生机制中发挥重要作用。现就胆汁酸、法尼醇核受体R、肠道微生态三者之间的相关性,及三者对肝衰竭和肝再生机制的作用方面进行综述,为临床肝衰竭的治疗提供新思路。
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| 关 键 词： | 肝功能衰竭 肝再生 胆汁酸 法尼醇核受体R 胃肠道微生物组 |
Mechanism of action of bile acid-farnesoid X receptor-intestinal microecological axis in the development of liver failure and liver regeneration |
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| CHEN Yanyan,LAN Yanmei,WANG Minggang,MAO Dewen. Mechanism of action of bile acid-farnesoid X receptor-intestinal microecological axis in the development of liver failure and liver regeneration[J]. Chinese Journal of Clinical Hepatology, 2021, 37(2): 480-484 |
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| Authors: | CHEN Yanyan LAN Yanmei WANG Minggang MAO Dewen |
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| Affiliation: | (Department of Basic Medicine,Hunan Traditional Chinese Medical College,Zhuzhou,Hunan 412000,China;Department of Scientific Research,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China;Department of Hepatology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China) |
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| Abstract: | Liver failure is a common critical medical disease,and extensive liver cell necrosis within a short period of time exceeds the regeneration capacity of liver cells and thus results in an extremely high fatality rate.Promotion of effective liver regeneration is the key to antagonizing liver failure.Recent studies have shown that bile acid,farnesoid X receptor(FXR),and intestinal microecology play an important role in liver failure and liver regeneration.This article reviews the association between bile acid,FXR,and intestinal microecology and their role in liver failure and liver regeneration,so as to provide new ideas for the treatment of liver failure in clinical practice. |
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| Keywords: | Liver Failure Liver Regeneration Bile Acid Farnesol Receptor R Gastrointestinal Microbiome |
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