冠状动脉钙化积分与冠状动脉疾病及全因性死亡相关性的Meta分析

目的系统评价冠状动脉钙化积分(CACS)与冠状动脉疾病(CAD)及全因死亡事件相关性。方法计算机检索Pubmed、The Cochrane Library、EMbase、CKNI、WanFang Data数据库,搜集CACS与CAD及全因性死亡(All-cause mortality)相关性的队列研究,检索时限从建库至2020年6月。由2名资料员提取文献并进行评价纳入研究的偏倚风险后,采用Stata 14.0软件进行Meta分析。结果纳入11个队列研究,包括59143例被研究者。Meta结果显示:与CACS<10相比,CACS≤100组[HR=2.46,95%CI(1.77,3.41),P=0.000,I^(2)=55.5%]、100

Meta analysis of correlation between coronary artery calcification score and coronary artery disease and all-cause mortality

Objective To systematically review the correlations among coronary artery calcification score(CACS), coronary artery disease and all-cause mortality. Methods The databases of Pubmed, The Cochrane Library, EMbase, CKNI and WanFang Data were electronically searched to collect cohort studies on the correlations between CACS, CAD and all-cause mortality from the inception of databases to June 2020. Meta analysis was performed with Stata 14.0 software when two data clerks independently screened literatures, they extracted data and assessed risk of bias of included studies. Results A total of 11 cohort studies were included, including 59 143 cases. The Meta results showed that CACS≤100 group [HR=2.46,95%CI(1.77,3.41),P=0.000,I²=55.5%],100HR=3.62,95%CI(2.24,5.83),P=0.000,I²=42.2%] and CACS>400 group [HR=5.09,95%CI(2.02,12.84),P=0.001,I²=70.7%] are more likely to occur CAD and all-cause deaths compared to CACS<10 group. Conclusion There is a higher risk of coronary artery disease and all-cause mortality for patients with CAC.