肺癌危险度与室内氡关系研究:中国两项研究的汇总分析结果

目的 居室氡暴露是导致肺癌死亡的第二位重要原因，这是地下矿工氡暴露研究的外推结果。本分析就是为了验证此预测的正确性。方法 中国进行的两项居室氡暴露肺癌病例-对照研究共包括1050肺癌病例和1996名对照，把这些数据汇总在一起进行分析。结果 根据线性模型，在95％置信区间情况下，每100Bq／m^3的附加比值比(EOR)为0．133(0．01，0．036)。对在现住所居住30a以上的调查对象进行分析，EOR值为0．315(0．07，0．91)。此估算值与矿工数据外推值及北美和欧洲室内氡研究结果类似。结论 在众多居室中普遍存在的氡浓度长期暴露，会使肺癌危险度增加。

Risk of Lung Cancer and Residential Radon:Pooled Results of Two Studies in China

Objective To verify the prognosis that miners' exposure to radon is the second leading cause of lung cancer. Methods We collected data from two case - control studies of residential radon representing two large radon studies conducted in China. The studies included 1 050 lung cancer cases and 1 996 controls.Results Based on a linear model, the excess odds ratio ( EOR) with 95% confidence intervals ( CI ) at 100 Bq/m3 was 0.133 (0.01,0.36) .For subjects living in the current home for 30 years or more, the EOR was 0.315 (0.07,0.91) . EOR estimates were similar to those in the extrapolations from miner data and consistent with residential radon studies in North American and Europe. Conclusion Long - terra radon exposure at concentrations found in many houses increases lung cancer risk.