| 三氧化二砷注射液治疗中晚期原发性肝胆癌的临床研究 |
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| 引用本文： | Qian J,Qin S,He Z. 三氧化二砷注射液治疗中晚期原发性肝胆癌的临床研究[J]. 中华肿瘤杂志, 2001, 23(6): 487-489 |
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| 作者姓名： | Qian J Qin S He Z |
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| 作者单位： | 解放军第八一医院全军肿瘤中心内科 |
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| 基金项目： | 江苏省青年科技基金资助项目(BQ98048);南京军区重点科研基金资助项目(NJ9804) |
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| 摘 要： | 目的 评价三氧化二砷（As2O3)治疗原发性肝胆癌的疗效和不良反应。方法 中晚期原发性肝胆癌共33例,其中肝癌29例,胆囊癌4例。单药As2O3注射液15mg,静脉滴注,1次／d,连用14－21d为一周期,间歇2周重复。结果 总缓解率15．2％,其中原发性肝癌PR4例,NC21例,PD4例。缓解率13．8％;胆囊癌CR1例,NC2例,PD1例。主要不良反应为轻度的骨髓抑制和肝功能损害。结论 As2O3治疗原发性肝胆癌有较好疗效,不良反应少,值得进一步深入研究。
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| 关 键 词： | 肝肿瘤 药物疗法 胆囊肿瘤 三氧化二砷 治疗 疗效 |
| 修稿时间： | 2001-04-19 |
Arsenic trioxide in the treatment of advanced primary liver and gallbladder cancer |
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| Qian J,Qin S,He Z. Arsenic trioxide in the treatment of advanced primary liver and gallbladder cancer[J]. Chinese Journal of Oncology, 2001, 23(6): 487-489 |
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| Authors: | Qian J Qin S He Z |
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| Affiliation: | Oncology Center, 81 Hospital, PLA, Nanjing 210002, China. |
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| Abstract: | Objective To evaluate the effect and toxicity of arsenic trioxide (As 2O 3) in treating primary liver and gallbladder cancer.Methods Twenty nine advanced primary liver cancer and 4 gallbladder cancer patients were treated with As 2O 3 injection only, 15 mg iv qd for 14 21 days and was repeated after 2 weeks.Results The overall response rate was 15.2%, 13.8% in primary liver cancer (PR 4, NC 21 and PD 4). It was 25.0% in gallbladder cancer (CR 1, NC 2, PD 1). The major side reactions were mild bone marrow suppression and hepatic functional damage. Conclusion As 2O 3 injection is effective in treating primary liver and gallbladder cancer with mild side reactions. It is worth studying in the future. [ |
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| Keywords: | Liver neoplasms/drug therapy Gallbladder neoplasms/drug therapy Arsenic trioxide/therapeutic use |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
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