| 宫颈癌放疗前后免疫功能改变及其临床意义 |
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| 引用本文： | 浦红,何成章,王丰,刘志辉.宫颈癌放疗前后免疫功能改变及其临床意义[J].中国免疫学杂志,2002,18(10):727-728,731. |
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| 作者姓名： | 浦红 何成章 王丰 刘志辉 |
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| 作者单位： | 1. 江苏省无锡市第四人民医院妇产科,无锡,214062
2. 江苏省无锡市第四人民医院中心实验室,无锡,214062 |
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| 摘 要： | 目的 :探讨放疗对宫颈癌患者免疫功能的影响。方法 :用流式细胞技术检测 2 2例宫颈癌患者放疗前后细胞免疫表型的改变 ,并与对照组进行比较。结果 :宫颈癌放疗前CD3 、CD4 、CD8 、CD3 CD4 均较对照组低 ,NK值较对照组高 ,但无显著性差异 ;放疗后CD3 、CD4 逐渐降低 ,CD8 和NK升高 ,CD3 CD4 逐渐降低 ,最后比例倒置 ,有显著性差异。结论 :宫颈癌患者免疫功能无明显抑制 ,放疗可损伤其免疫功能 ,提示放疗期间应辅以免疫治疗。
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| 关 键 词： | 宫颈癌 放射治疗 T淋巴细胞亚群 NK细胞 流式细胞术 |
| 文章编号： | 1000-484X(2002)10-0727-03 |
The changes of immunity and clinical significance in patients with cervical cancer before and after radiotherapy |
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| PU Hong,HE Cheng-Zhang,WANG Feng et al.The changes of immunity and clinical significance in patients with cervical cancer before and after radiotherapy[J].Chinese Journal of Immunology,2002,18(10):727-728,731. |
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| Authors: | PU Hong HE Cheng-Zhang WANG Feng |
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| Institution: | PU Hong,HE Cheng-Zhang,WANG Feng et al.The Forth People's Hospital of Wuxi,Wuxi 214062 |
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| Abstract: | Objective:To investigate the influence of radiotherapy on immunity of patients with cervical cancer Methods:22 cancer patients and 20 patients with gynecological benign tumor were immunothenotype by flow cytometry Results:There was no obvious difference in immunity between cancer patients and control group After radiopherapy, ratio CD3 /CD4 decreased and the number of CD8 and NK cells increased in cancer patients Conclusion:No immunodepression appeared in patients with cervical cancer before therapy Radiotherapy decreased immunity, which indicates adjuvant immunotherapy should be given during radiotherapy |
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| Keywords: | Cervical cancer Radiotherapy T lymphocyte subset Natural kill cells Flow cytometry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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