| 0,0—二乙酰蝙蝠葛苏林碱对突触体钙内流的... |
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| 引用本文： | 鲁友明,刘国卿.0,0—二乙酰蝙蝠葛苏林碱对突触体钙内流的...[J].中国药理学报,1991,12(6):494-496. |
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| 作者姓名： | 鲁友明 刘国卿 |
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| 摘 要： |
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| 关 键 词： | 蝙蝠葛苏林碱 突触体 |
Inhibitory effect of 0,0-bisacetyldaurisoline on Ca2+ influx into synaptosomes. |
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| Y M Lu,G Q Liu.Inhibitory effect of 0,0-bisacetyldaurisoline on Ca2+ influx into synaptosomes.[J].Acta Pharmacologica Sinica,1991,12(6):494-496. |
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| Authors: | Y M Lu G Q Liu |
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| Institution: | Department of Molecular Pharmacology, Naval Neurobiology Research Centre, Nanjing, China. |
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| Abstract: | The inhibitory effects of 0,0-bisacetyldaurisoline (BDSL) on 45Ca2+ uptake and 3H]GABA release from synaptosomes were investigated. BDSL (1-100 mumol.L-1) produced a concentration-related inhibition of high K(+)-stimulated 45Ca2+ uptake and 3H]GABA release (IC50 = 5.6 +/- 0.7 and 31.4 +/- 2.3 mumol.L-1, respectively) in synaptosomes but verapamil (Ver) was only weakly active. Neither BDSL (100 mumol.L-1) nor Ver (100 mumol.L-1) modified 45Ca2+ uptake in control medium (K+ 5 mmol.L-1 resting uptake) and 3H]GABA release in Ca(2+)-free medium (K+ 45 mmol.L-1 basal release). The results suggest that BDSL may be a potent Ca2+ channel blocker in neurons. |
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