甲醛染毒大鼠脂质过氧化水平分析

用不同剂量（５，１０，２０，５０，１００ｍｇ／ｋｇ）甲醛经腹腔注射染毒ＳＤ大鼠后２４小时，以及１０ｍｇ／ｋｇ染毒后２，６，２４小时收集大鼠血和肝脏。对样品的测定结果显示，红细胞ＳＯＤ活性，全血ＧＳＨ－ＰＸ活性，红细胞内谷胱甘肽含量以及血浆与肝组织ＭＤＡ浓度等五项指标与染毒剂量均有不同程度相关，其中红细胞ＳＯＤ对甲醛最为敏感，５ｍｇ／ｋｇ时就比对照组有明显降低，在时间效应关系中可以见到红细胞内ＳＯＤ

STUDY ON LIPID PEROXIDE IN THE BLOOD AND LIVER OF FORMALDEHYDE TREATED RATS

The blood and livers of rats were collected 24 hrs. after i. p. administration of formaldehyde (5 ) 10,, 20, 50 mg/kg ). The activity of blood glutathione peroxidase (GSH-PX),superoxide dismutase (SOD) activities, glutathione conte nt in erythrocyte and the concentration ofmalondialdehyde (MDA) in plasma and liver were investigated. The results showed that therewas a significant relationship between the four indexes and the dosages. SOD in erythrocytewas the most susceptible to formaldehyde. The content of GSH in erythrocyte and MDA inplasma changed significantly compared with those of controls when treated with formaldehyde(10mg/kg) 2 hrs. later. They resumed to the level of controls 24 hrs. after the treatment. Theactivity of SOD and GSH-PX became lower and lower at 2, 6, 24 hrs. after the treatment. Thisexperiment revealed that formaldehyde might initiate lipid peroxide,which in turn would damage the activity of SOD and GSH-PX and reduce the content of GSH in erythrocyte.