Adaptation to periodic hypoxia and a diet supplemented with polyunsaturated class ω-3 fatty acids enhance the resistance of Ca2+ transport in the myocardial sarcoplasmic reticulum to free-radical oxidation |
| |
Authors: | T G Sazontova Yu V Arkhipenko F Z Meerson |
| |
Institution: | (1) Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow |
| |
Abstract: | The relationship between the level of accumulation of lipid peroxidation products and the status of the Ca2+-transporting system in the sarcoplasmic reticulum of the rat myocardium is studied against the background of two cardioprotective
factors, namely adaptation to periodic hypoxia and a diet enriched in polyunsaturated fatty acids of the ω-3 class. It is
shown that the diet leads to an increase of level of lipid peroxidation products by 1.8 times in the heart and by 19 times
in the liver, whereas a adaptation has no effect on the level of lipid peroxidation products in either of these organs. At
the same time, the combined action of both factors considerably enhances the resistance of the myocardial Ca2+-transporting system to free radical-induced oxidation. Inin vitro experiments it is shown that adaptation to periodic hypoxia results in a more than twofold deceleration of Ca2+ transport inhibition during the oxidation induction by the Fe2+/ascorbate system; the diet causes a 3.5-fold deceleration of such inhibition. The results show that the accumulation of a
high level of lipid peroxidation products is not always followed by damage to the Ca2+-transporting system in the myocardial sarcoplasmic reticulum.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
7, pp. 42–45, July, 1995
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences |
| |
Keywords: | polyunsaturated fatty acids adaptation lipid peroxidation Ca 2+ transport myocardium |
本文献已被 SpringerLink 等数据库收录! |
|