入院后早期阿托伐他汀治疗对不稳定型心绞痛患者血清炎症因子的影响

目的探讨不稳定心绞痛（UA）患者入院后立即给予阿托伐他汀治疗对血清炎症因子水平的影响。方法连续入选87例UA患者,随机分为早期组（43例）,即入院后立刻给予阿托伐他汀20mg,其后予阿托伐他汀20mg/d;常规组（44例）,按常规处方接受阿托伐他汀20mg/d治疗,于入院时和1周后测定血清高敏C反应蛋白（hs-CRP）、肿瘤坏死因子α（TNF-α）和白介素6（IL-6）水平。结果阿托伐他汀治疗1周后,早期组血清hs-CRP、TNF-α及IL-6水平较前明显降低,并低于同期常规组,而与总胆固醇和低密度脂蛋白胆固醇水平的变化不相关。结论对UA患者更早开始他汀类药物治疗可能更有利于早期对炎症反应的抑制。

Effect of early treatment with atorvastatin on serum levels of inflammatory cytokines in patients with unstable angina pectoris

Objective To investigate the effect of very early intervention by atorvastatin on inflammatory cytokines in patients with unstable angina（UA）. Methods Eighty-seven consecutive patients with UA were divided randomly into two groups： early intervention group （n=43） and routine treatment group （n=44）. Patients in early intervention group received atorvastatin 20mg immediately after admission,followed by regular administration （20mg/d）. Patients in routine treatment group received regular administration of atorvastatin 20mg/d only. Blood samples were collected at admission and one week later. The high sensitive-c reactive protein（hs-CRP）,tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）levels were determined. Results The serum hs-CRP,TNFα,IL-6 levels were significantly reduced in early intervention group,and lower than that in routine treatment group one week after admission. They were not correlated with the changes of TC and LDL-C levels. Conclusion The earliest possible use of statin may have more significant anti-inflammation effects on patients with UA.