| 医用生物蛋白胶对注射型骨形态发生蛋白成骨活性的影响 |
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| 引用本文： | 王登虎,刘建,李丹,胡蕴玉,袁志.医用生物蛋白胶对注射型骨形态发生蛋白成骨活性的影响[J].中国组织工程研究与临床康复,2002,6(24):3766-3767. |
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| 作者姓名： | 王登虎 刘建 李丹 胡蕴玉 袁志 |
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| 作者单位： | XijingHospital，FourthMilitaryMedicalUniversity，XijingHospital，FourthMilitaryMedicalUniversity，XijingHospital，FourthMilitaryMedicalUniversity，XijingHospital，FourthMilitaryMedicalUniversity，XijingHospital，FourthMilitaryMedicalUniversity Xi'an710032，China，Xi'an710032，China，Xi'an710032，China，Xi'an710032，China，Xi'an710032，China |
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| 摘 要： | Inject-typeBMP(bBMP/rhbFGF/PVP)powerwasusedasaccessorialtreatmentoffreshfracture,delayhealorboneIncoher-enceandgainedgoodeffects.WeobservedeffectofBMPonco-agulabilityofFSandinfluenceofFSonosteoinductiveabilityofBMPanddiscussthefeasibilityofusingFSassolventofBMP.1Subjectsandmethods1.1Subjects1.1.1Inject-typeBMPandfibrinsealant(FS)Inject-typeBMPisprovidedbyorthopedicsresearchinstituteofXijingHos-pitaloftheFourthMilitaryMedicalUniversity.FSisprovidedbyGuanzhouBeiteBiotechnolog…
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Influence of fibrin sealant on osteoinductive ability of inject-type bone morphogenetic protein |
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| WANG Deng-hu,LIU Jian,LI Dan,HU Yun-yu,YUAN Zhi.Influence of fibrin sealant on osteoinductive ability of inject-type bone morphogenetic protein[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2002,6(24):3766-3767. |
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| Authors: | WANG Deng-hu LIU Jian LI Dan HU Yun-yu YUAN Zhi |
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| Abstract: | Objective To observe influence of fibrin seala nt (FS)on osteoinductive ability of inject-type BMP.Method The inject-type BMP power was dissolved in the main glue p art or thrombin part of FS,then mixed with the main glue part or thrombin pa rt of FS into gel,observe coagulating time,then implant comp osite into the thigh muscle pouch of m ice to evaluate their capacity to induce new bone formation,and compared to the single BMP implant gr oup.Result There was no difference in the coagul ating time between two mixing method,the osteoin-ductive ability of implants BMP dissolved in the main glue part or thrombin part of FS group was higher than that of simply BMP implant group.Conclusion FS was perfect carrier to inject-type BMP. |
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| Keywords: | bone morphogenetic protein fibrin sealant basic fibroblast growth fa ctor carrier |
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