| 布洛芬糖浆剂药动学及相对生物利用度 |
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| 引用本文： | 王润玲,董伟林,封春梅,李薇,陈涓,刘印忠.布洛芬糖浆剂药动学及相对生物利用度[J].中国药学杂志,1997,32(10):601-603. |
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| 作者姓名： | 王润玲 董伟林 封春梅 李薇 陈涓 刘印忠 |
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| 作者单位： | 天津医科大学药学系，天津医科大学实验中心 |
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| 摘 要： | 目的：测定布洛芬糖浆剂的药动学及相对生物利用度。方法：8名健康男性志愿者单剂量随机交叉po400mg布洛芬后，采用HPLC测定血浆药物浓度。结果：口服糖浆剂及片剂后血药浓度达峰时间分别为（0．86±0．30）h和（1．78±0．34）h，峰浓度分别为（48．9±9．71）μg·ml－1和（44．2±8．23）μg·ml－1，药 时曲线下面积分别为（175．1±31．9）μg·h·ml－1和（178．6±23．2）μg·h·ml－1。结论：统计分析表明，糖浆剂较片剂达峰时间短，吸收快。布洛芬糖浆剂相对生物利用度为（98．3±14．5）％。
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| 关 键 词： | 布洛芬 糖浆剂 生物利用度 药动学 |
| 收稿时间： | 1997-02-13; |
Pharmacokinetics and relative bioavailability of ibuprofen syrup |
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| Wang Runling.Pharmacokinetics and relative bioavailability of ibuprofen syrup[J].Chinese Pharmaceutical Journal,1997,32(10):601-603. |
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| Authors: | Wang Runling |
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| Institution: | (Wang RL),Dong Weilin(Dong WL),Feng Chunmei(Feng CM),et a |
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| Abstract: | OBJECTIVE: To determine the pharmacokinetics and relative bioavailability of ibuprofen syrup. METHODS: The drug concentration in plasma was assayed by HPLC method after administration of a single oral dose of 400 mg ibuprofen to each of 8 healthy male volunteers. RESULTS: The peak levels (tp) in plasma averaged (48.9±9.71)μg·ml-1 and (44.2±8.23)μg·ml-1 at (0.86±0.30)h and (1.78±0.34)h, and the areas under the drug concentration curves (AUC) were (175.1±31.9)μg·h·ml-1 and (178.6±23.2)μg·h·ml-1 for ibuprofen syrup and tablets, respectively. CONCLUSION: The result of statistical analysis showed that the syrup could reach peak level faster than tablets. |
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| Keywords: | ibuprofen syrup bioavailability pharmacokinetics |
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