Correlation between E-cadherin and CD44 adhesion molecules expression and cervical lymph node metastasis in oral tongue SCC: Predictive significance or not |
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Authors: | Mostaan Leila Vazifeh Khorsandi Mohammad Taghi Sharifian Shahriar-Mohammad Reza Shandiz Fatemeh Homee Mirashrafi Fatemeh Sabzari Homa Badiee Reza Borghei Hasti Yazdani Nasrin |
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Affiliation: | a Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran b Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran |
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Abstract: | The aim of this article was to evaluate the expression of E-cadherin and CD44 adhesion molecule in oral tongue squamous cell carcinoma (SCC) since inappropriate expression of adhesion molecules raises the metastatic ability of the tumor cells.Biopsy specimens from 92 patients with tongue SCC were examined for the expression of E-cadherin and CD44 by immunohistochemistry. The relationship of immunoreactivity with tumor stage and cervical lymph node metastasis was then analyzed.Sixty-one patients (66.3%) had reduced or negative staining for CD44. Weak or absent staining for E-cadherin was seen in 14 patients (15.21%). Cervical lymph node metastasis is associated with decreased or negative staining for CD44, but no association was found between E-cadherin immunoreactivity and nodal metastasis.Our study reveals that reduced expression of CD44 could be an indicator of high invasiveness of tumor by increasing cervical lymph node metastasis. |
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Keywords: | Tongue Squamous cell carcinoma Lymph node metastasis E-cadherin CD44 |
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