Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders |
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Authors: | Roberto Marconi Angelo Antonini Paolo Barone Carlo Colosimo Tania P. Avarello Edo Bottacchi Antonino Cannas Maria G. Ceravolo Roberto Ceravolo Giulio Cicarelli Rosa M. Gaglio Luisa Giglia Francesco Iemolo Michela Manfredi Giuseppe Meco Alessandra Nicoletti Massimo Pederzoli Alfredo Petrone Antonio Pisani Francesco E. Pontieri Rocco Quatrale Silvia Ramat Rossana Scala Giampiero Volpe Salvatore Zappulla Anna Rita Bentivoglio Fabrizio Stocchi Giorgio Trianni Paolo Del Dotto Danilo De Gaspari Lucia Grasso Francesca Morgante Gabriella Santangelo Giovanni Fabbrini Letterio Morgante |
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Affiliation: | Dipartimento di Neuroscienze, Ospedale Misericordia, Via Senese, 171, 58100, Grosseto, Italy. r.marconi@usl9.toscana.it |
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Abstract: | Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score ≤ 23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score ≤ 3.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.005). Age (OR = 1.05), cognitive impairment (OR = 9.54), lack of cardiovascular symptoms (OR = 3.25), attention or memory problems (OR = 0.59) and treatment with L: -DOPA (OR = 5.58) were predictors of frontal lobe dysfunction. MMSE was negatively associated with all FAB items (β ≤ -0.16) and age with all FAB items but prehension behavior (β ≤ -0.01). Previous use of L: -DOPA was negatively associated with verbal fluency (β = -0.32) possibly acting as surrogate marker of disease duration. Cognitive impairment is a predictor of frontal lobe dysfunction. Among NMS, lack of attention or memory problems were negatively associated with frontal impairment. Further studies are nonetheless needed to better identify the predictors of frontal impairment in PD patients. |
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