| 组织因子及组织因子途径抑制物在急性脑血管意外并发神经源性肺水肿中的变化研究 |
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| 引用本文： | 徐兆军,别华容,田敏,郑智娟,张冬菊.组织因子及组织因子途径抑制物在急性脑血管意外并发神经源性肺水肿中的变化研究[J].中国医药导报,2011,8(32):39-40. |
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| 作者姓名： | 徐兆军 别华容 田敏 郑智娟 张冬菊 |
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| 作者单位： | 湖北省天门市第一人民医院急诊科,湖北天门,431700 |
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| 摘 要： | 目的：探讨急性脑血管意外并发神经源性肺水肿（NPE）中组织因子（TF）及其抑制物（TFPI）的变化情况。方法：选择我院2007年6月～2010年5月收治的急性脑血管意外患者80例为研究组，其中，脑出血36例，脑梗死44例，选择同期健康体检者40例为对照组，分别采用酶联免疫吸附抗原法检测患者血浆TF、TFPI，并进行组问比较。结果：研究组患者血TF值均高于对照组，差异均有高度统计学意义（均P〈0．01）；研究组中，脑出血患者血TFPI高于对照组，脑梗死患者血TFPI低于对照组，差异均有统计学意义（均P〈0．05）。脑出血及脑梗死患者中并发神经源性肺水肿的患者，血TF、TFPI均高于未并发的神经源性肺水肿患者，差异有统计学意义（P〈0．05）。结论：急性脑血管意外并发神经源性肺水肿的发生与凝血异常、炎症反应有关，组织因子及组织因子抑制物可能参与了肺损伤发生发展的过程。
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| 关 键 词： | 急性脑血管意外 神经源性肺水肿 组织因子 组织因子途径抑制物 |
Changes of tissue factor and tissue factor pathway inhibitor in acute cerebral vascular accident complicated neurogenic pulmonary edema |
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| XU Zhaojun,BIE Huarong,TIAN Min,ZHENG Zhijuan,ZHANG Dongju.Changes of tissue factor and tissue factor pathway inhibitor in acute cerebral vascular accident complicated neurogenic pulmonary edema[J].China Medical Herald,2011,8(32):39-40. |
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| Authors: | XU Zhaojun BIE Huarong TIAN Min ZHENG Zhijuan ZHANG Dongju |
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| Institution: | XU Zhaojun,BIE Huarong,TIAN Min,ZHENG Zhijuan,ZHANG Dongju Department of Emergency,the First People's Hospital in Tianmen City,Hubei Province,Tianmen 431700,China |
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| Abstract: | Objective:To investigate the changes of tissue factor(TF) and tissue factor pathway inhibitor(TFPI) in acute cerebral vascular accident complicated neurogenic pulmonary edema.Methods:80 patients with acute cerebral vascular accident of which 36 cases of cerebral hemorrhage,44 cases of cerebral infarction in our hospital from June 2007 to May 2010 were selected as the study group,40 cases of healthy in the same period were chosen as the control group.TF,TFPI detected by ELISA technique and the results were c... |
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| Keywords: | Acute cerebral vascular accident Neurogenic pulmonary edema Tissue factor Tissue factor pathway inhibitor |
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