| 肝细胞癌中HBx蛋白与生存素蛋白表达的关系及其意义 |
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| 引用本文： | 陈江,崔彬,姜汉国. 肝细胞癌中HBx蛋白与生存素蛋白表达的关系及其意义[J]. 中国医药导报, 2011, 8(35): 22-23,28 |
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| 作者姓名： | 陈江 崔彬 姜汉国 |
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| 作者单位： | 广东省廉江市人民医院肿瘤科,广东廉江,524400 |
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| 摘 要： | 目的：探讨乙型肝炎病毒X蛋白（HBx）与生存素在肝细胞癌（HCC）表达发生中的作用。方法：采用免疫组织化学测定58例患者的HCC组织中HBx蛋白和生存素蛋白表达,用含有辣根过氧化物酶底物的试剂合（DAB）显色,已知的肝癌组织HBx及生存素阳性切片为阳性对照,磷酸盐缓冲液（PBS）作为空白对照。结果：HCC组织HBx和生存素的表达率分别为46.6%（27/58）和69.0%（40/58）,HBx蛋白阳性的HCC组织中生存素蛋白阳性表的阳性率为70.4%（19/27）,HBx蛋白的阴性的HCC组织中生存素蛋白阳性表的阳性率为27.5%（11/40）,差异有统计学意义（P〈0.05）;HBx蛋白与生存素蛋白表达与HCC分化程度、转移及甲胎蛋白（AFP）相关。结论：在HCC的发生过程中HBx蛋白可上调生存素蛋白的表达,促进肝细胞癌的发生发展。
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| 关 键 词： | 肝细胞癌 乙型肝炎病毒X蛋白 肝炎病毒 生存素 凋亡 |
The significance and relationship between HBx protein and survivin portein expression in hepatic cellular cancer |
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| CHEN Jiang,CUI Bin,JIANG Hanguo. The significance and relationship between HBx protein and survivin portein expression in hepatic cellular cancer[J]. China Medical Herald, 2011, 8(35): 22-23,28 |
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| Authors: | CHEN Jiang CUI Bin JIANG Hanguo |
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| Affiliation: | CHEN Jiang,CUI Bin,JIANG Hanguo Department of Oncology,the people's Hospital of Lianjiang City,Guangdong Province,Lianjiang 524400,China |
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| Abstract: | Objectve: To investigate the effect of HBx protein and survivin protein in the expression of hepatic cellular cancer.Methods: The expression of HBx and survivin protein in hepatic cellular cancer tissues of 58 patients were detected by immunohistochemistry method,the protein was colorated by DAB,the positive pathological section of HBx and survivin in hepatic cellular cancer was taken as positive control,while PBS was taken as blank control.Results: The positive rates of HBx and survivin were 46.6%(27/58) a... |
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| Keywords: | Hepatic cellular cancer HBx Hepatitis virus Survivin portein Apoptosis |
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