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| 孕酮对视网膜缺血再灌注损伤神经元凋亡的影响 | |
| 引用本文： | 雷晓溪,鄢秀菊,刘苏,吴君,王莉.孕酮对视网膜缺血再灌注损伤神经元凋亡的影响[J].中国医药导报,2011,8(35):15-16,19. |
| 作者姓名： | 雷晓溪 鄢秀菊 刘苏 吴君 王莉 |
| 作者单位： | 1. 广东省东莞市南城人民医院眼科,广东东莞,523071 2. 重庆市第一人民医院视明眼科中心,重庆,400040 3. 重庆医科大学附属第二医院眼科中心,重庆,400010 |
| 摘 要： | 目的：研究孕酮预处理对视网膜缺血再灌注损伤后神经元凋亡的影响,并探讨其对视神经保护的可能机制。方法：用升高眼压的方法制作兔视网膜缺血再灌注模型,将36只新西兰大白兔随机分为正常组（n=4）、对照组（n=16）和孕酮组（n=16）。缺血再灌注模型制作前24 h,给予对照组兔耳缘静脉注射生理盐水4 ml/kg,孕酮组兔耳缘静脉注射孕酮4 mg/kg。观察缺血再灌注后不同时段对照组与孕酮组视网膜组织学变化和Bcl-2的蛋白表达及凋亡情况。结果：视网膜缺血再灌注各时间段,HE染色显示,孕酮组视网膜内层厚度均较对照组厚,且内核层细胞数较多,差异均有统计学意义（均P〈0.05）;凋亡检测结果显示,缺血再灌注24 h时凋亡达高峰,孕酮组内核层的凋亡细胞少于对照组,差异有统计学意义（P〈0.05）;孕酮组和对照组在缺血再灌注12 h时均检测到Bcl-2蛋白表达,孕酮组Bcl-2蛋白表达水平较对照组少（P〈0.05）。结论：孕酮预处理可以促进视网膜缺血再灌注后细胞的存留,减少细胞凋亡,对视神经损伤具有保护作用。 |
| 关 键 词： | 孕酮 视网膜缺血 视神经损伤 凋亡 神经保护 |
Influence of progesterone on neuronal apoptosis after retinal ischemia reper-fusion injury |
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| LEI Xiaoxi,YAN Xiuju,LIU Su,WU Jun,WANG Li.Influence of progesterone on neuronal apoptosis after retinal ischemia reper-fusion injury[J].China Medical Herald,2011,8(35):15-16,19. | |
| Authors: | LEI Xiaoxi YAN Xiuju LIU Su WU Jun WANG Li |
| Institution: | LEI Xiaoxi1,YAN Xiuju2,LIU Su3,WU Jun1,WANG Li1 1.Department of Ophthalmology,Nancheng People's Hospital of Dongguan City,Guangdong Province,Dongguan 523071,China,2.Shiming Ophthalmology Center,the First People's Hospital of Chongqing City,Chongqing 400040,3.Center of Ophthalmology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010 |
| Abstract: | Objective: To study the influence of progesterone pretreatment on neuronal apoptosis after retinal ischemia reperfusion injury and investigate its potential protection mechanism for optic nerves.Methods: The intraocular pressure elevation method was used to build the rabbit retinal ischemia reperfusion model.36 New Zealand white rabbits were randomly divided into normal group(n=4),control group(n=16) and progesterone group(n=16).24 h before ischemia,the control group was treated with intravenous injection o... |
| Keywords: | Progesterone Retinal ischemia Optic nerve injury Apoptosis Neuroprotection |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |