| 长期饮酒对大鼠内外源性肺损伤时还原性谷胱甘肽、超氧化物歧化酶和丙二醛的影响 |
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| 引用本文： | 刘义德,刘志.长期饮酒对大鼠内外源性肺损伤时还原性谷胱甘肽、超氧化物歧化酶和丙二醛的影响[J].中国医药导报,2011,8(35):12-14. |
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| 作者姓名： | 刘义德 刘志 |
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| 作者单位： | 1. 沈阳急救中心急诊科,辽宁沈阳,110006
2. 中国医科大学附属第一医院急诊科,辽宁沈阳,110001 |
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| 摘 要： | 目的：探讨长期饮酒对内外源性肺损伤时氧化还原功能的影响。方法：采用长期饮酒后内、外源性肺损伤大鼠模型进行动脉血气、肺湿干比（W/D）和肺、肝组织还原性谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、丙二醛（MDA）检测。结果：长期饮酒后内、外源性肺损伤组大鼠肺、肝组织GSH水平较饮水损伤组明显下降,MDA水平显著升高,且外源性肺损伤组GSH、MDA改变较内源性肺损伤明显,差异均有统计学意义（P〈0.05）。结论：长期饮酒导致肺脏抗氧化功能下降,加重了内、外源因素引起的肺损伤。
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| 关 键 词： | 长期饮酒 急性肺损伤 谷胱甘肽 |
The influence of chronic alcohol ingestion on glutathione, superoxide dismu-tase, malonaldehyde in rats with endogenous and external acute lung injury |
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| LIU Yide,LIU Zhi.The influence of chronic alcohol ingestion on glutathione, superoxide dismu-tase, malonaldehyde in rats with endogenous and external acute lung injury[J].China Medical Herald,2011,8(35):12-14. |
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| Authors: | LIU Yide LIU Zhi |
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| Institution: | LIU Yide1,LIU Zhi2 1.Department of Emergency,Shenyang Emergency Center,Liaoning Province,Shenyang 110006,China,2.Department of Emergency,the First Affiliated Hospital of Chinese Medical University,Shenyang 110001 |
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| Abstract: | Objective: To explore the influence of chronic alcohol ingestion on redox function in rats with endogenous and external acute lung injury.Methods: The changs of PaO2,W/D value and the level of lutathione(GSH),superoxide dismutase(SOD),malonaldehyde(MDA) in lung and liver constitution of rats with acute lung injury caused by pulmonary and extrapulmonary disease were observed.Results: The levels of GSH in lung and liver tissue were statistically decreased,at the same time MDA level increased in alcohol-injury... |
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| Keywords: | Chronic alcohol ingestion Acute lung injury Glutathione |
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