丙型肝炎患者生化变量与细胞因子间的相关性分析

目的：研究丙型肝炎病毒感染后血液生化变量与细胞因子重组人干扰素γ（interferon-1，IFN-γ）、肿瘤坏死因子仪（tumornecrosisfactor，TNF—α）、重组人白介素10（interleukin-10，IL-10）之间的相关性。方法：以66例丙型肝炎患者为材料，利用统计学软件，分析丙型肝炎患者各生化指标之间及与3种细胞因子间的相关性。结果：①除球蛋白（GLO）与TNF—d在0．05置信水平上有较低相关性（r=-0．287，P=0．046）之外，各生化变量与各细胞因子之间无明显相关性。②各生化变量之间，丙氨酸氨基转换酶（ALT）与天门冬酸氨基转换酶（AST）有显著的相关性（r=0．869，P=0），做除法后（ALT／AST）相关性基本被消除，各变量之间存在微弱互相关性。③除IFN-γ与TNF—α之间存在弱相关性（r=-0．448，P=0．009）之外，各炎症细胞因子之间无明显相关性。结论：各生化指标之间、3种炎症细胞因子之间、各生化变量与3种炎症细胞因子间的相关性均较差。

Correlation between biochemical indicators and cytokines in hepatitis C patients

Objective： To study the correlation between biochemical indicators and cytokines of interferon-γ（IFN-γ）, tu- mor necrosis factor （TNF-α, interleukin-10 （IL-10） in hepatitis C patients. Methods： 66 patients with hepatitis C were se- lected as the material, the statistical software was used to analyze the correlation between biochemical indicators and the three eytokines in the 66 patients. Results： （1）There was a lower correlation between GLO and TNF （r=-0.287, P=0.046）, all biochemical indicators and the cytokines had no significant correlation. （2）There was a significantly correlation between ALT and AST （r=0.869, P=0）. （3）There was a weak correlation between IFN-γand TNF-α （r=0.448, P=0.009）, there was no significant correlation among other cytokines. Conclusion： There are lower correlations not only in various biochemical indicators and in cytokines, but also between biochemical indicators and three eytokines.