匹维溴胺联合谷维素治疗老年肠易激综合征临床疗效观察

目的：探讨匹维溴胺联合谷维素治疗老年肠易激综合征的临床疗效及安全性。方法：选择我院消化内科于2009年3月～2010年7月收治的老年肠易激综合征患者73例，其中，男55例，女18例；平均年龄（65．7＋6．4）岁，按照随机数字表法将其分为试验组（n=37）和对照组（n=36）。试验组患者给予匹维溴胺治疗，每日3次，每次50mg，另给予谷维素治疗，每日3次，每次30mg。对照组患者只给予匹维溴胺治疗，每日3次，每次50mg。两组研究均以30d为1个疗程，评估两组的临床治疗效果及不良反应。结果：试验组和对照组的显效率分别为62．3％和27．8％，两组在显效率方面比较，差异有统计学意义（X^2=6．37，P〈0．05）。试验组和对照组的总有效率分别为89．2％和61．1％，两组在总有效率方面比较，差异有统计学意义（x^2=7．45，P〈O．05）。两组均未出现明显不良反应，患者耐受性好。结论：匹维溴胺联合谷维素治疗老年肠易激综合征疗效明显，不良反应轻微，值得临床推广。

Investigation of Pinaverium bromide combined with Oryzanol in the treatment of older patients with irritable bowel syndrome

Objective： To investigate clinical efficacy and safety of Pinaverinm bromide combined with Oryzanol in the treatment of older patients with irritable bowel syndrome. Methods： 73 older patients with irritable bowel syndrome （Rome I1 diagnostic criteria for functional bowel disorders） who hospitalized in our hospital from March 2009 to July 2010 were randomly divided into two groups： test group （n=37） and control group （n=36）. Control group was given Pinaverium bromide, three times a day, each time 50 mg. Test group was given Oryzanol three times a day, each time 30 mg on the basis of con- trol group. One cycle included 30 days, the clinical effect was observed. Results＇ The Effective rate of the test group and control group was 62.3% and 27.8% respectively, there was significant difference between the two groups （X^2=6.37, P〈 0.05）. The total effective rate of test group and control group was 89.2% and 61.1% respectively, there was significant difference between the two groups （X^2=7.45, P〈0.05）. Conclusion： Oryzanol plus Pinaverium bromide in the treatment of older patients with irritable bowel syndrome has better clinical efficacy, mild adverse reactions and it is worthy of promotion.