卡托普利对大鼠心肌组织丝裂素活化蛋白激酶表达的影响

目的　探讨卡托普利对肾性高血压大鼠心肌组织丝裂素活化蛋白激酶 (MAPK)表达的影响。方法　复制二肾一夹高血压动物模型作为实验组 ,术后 4周开始给予卡托普利者作为治疗组 ,以未进行二肾一夹者为对照组。术后 8周测定动脉血压、心肌肥大指数及心肌组织MAPK的表达。结果　与对照组相比 ,实验组动脉血压及心肌肥大指数显著升高 ,MAPK表达显著增强 (P <0 .0 1) ;卡托普利显著降低心肌MAPK的表达。结论　心肌MAPK表达增强可能是血管紧张素II介导的心肌肥大信号转导通路中的重要环节。

Affects of captopril on expression of mitogen-activated proten kinase in myocardium of renal hypertension rats

Objective To investigate the affects of captopril on expression of mitogen-activated proten kinase (MAPK) in hypertrophic myocardium of renal hypertension rats.Method The rats modle of renal hypertension were made by two-kidney, one-clip as experiment group, the animals with captopril treatment at 4～8 weeks as treatment group, the animal with non-operation as control group.The blood pressure, cardiac hypertrophy parameter and expression of MAPK in myocardium were measured at eighth week. Results The blood pressure, cardiac hypertrophy parameter and expression of MAPK increased significantly in experiment group compared with control group at eighth week(P<0.01).The expression of MAPK significantly decreased in treatment group with captopril.Conclusion Maybe the expression of increased MAPK induced by AngII play an important role in single transduction pathway of hypertrophic myocardium in renal hypertension