有机磷中毒中间综合征患者血栓前状态的研究

目的了解急性有机磷中毒中间综合征（IMS）患者血栓前状态变化情况。方法对23例IMS患者血清P-选择素（Ps）、尿激酶型纤溶酶原激活物（uPA）、纤溶酶原激活物抑制物（PAI）和血管性血友病因子（vWF）水平进行检测，并与21例健康体检者（对照组）和20例急性有机磷中毒非中间综合征组（AOPP组）比较。结果IMS组血清Ps、uPA和vWF水平分别为（42.38±14.12）pg／L、（1.68±0.52）μg/L、（164.33±33.16）％；AOPP组分别为（31.57±12.31）pg／L、（1.23±0.41）μg／L、（135.45±31.21）％；对照组分别为（21.62±12.27）pg／L、（0.61±0.42）μg／L、（112.27±31.41）％。IMs组高于对照组和AOPP组（P〈0.01或P〈0.05）；PAI：IMs组为（1.36±0.38）Au／ml，AOPP组为（0.93±0.31）Au／ml，对照组为（0.74±0.29）Au／ml，IMS组低于对照组和AOPP组（P〈0.01或P〈0.05）。结论IMS患者机体纤溶功能受损，表现为纤溶亢进，其受损程度较AOPP患者重。

Research on prethrombotic state of the organophosphate poisoning in patients with intermediate syndrome

Objective To comprehend the prethrombotic state changes of acute organophosphate poisoning in patients with intermediate syndrome. Methods 23 cases of patients with IMS , P-selectin （Ps） , urokinase-type plasminogen activator （uPA）, plasminogen activator inhibitor （PAI） and yon Willebrand factor （vWF） levels were detected , and compared with 21 cases of healthy persons （ control group） and 20 cases of acute organophosphate poisoning intermediate syndrome （AOPP） group. Results IMS serum Ps, uPA and vWF levels were （42.38±14.12） pg/L, （1.68±0.52）μg/L, （164.33±33.16）% ; AOPP group were （31.571±12.31） pg/L, （1.23±0.41）μg/L, （135.45±31.21）% ; control group were （21.62±12.27）pg/L, （0.61±0.42）μg/L, （112.27±31.41）%. IMS Group was higher than AOPP group and the control group （P〈0.01 or P 〈0.05） ; PIA ： IMS Group was （136± 0.38） Au/ml, AOPP group was （0.93±0.31） Au/ml, and control group was （0.74±0.29） Au/ml,IMS group was lower than the control group and the AOPP group（ P 〈0.01 or P〈 0.05）. Conclusion The IMS patients＇ fibrinolytic function was impaired that performanced as hyperfibroidism, and its impairment was more severe than the AOPP.