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Determination of IgG subclasses of immunoglobulin preparations for intravenous injection and the problems involved |
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| Authors: | Yoshiaki Tokano Yoshimi Umezawa Ko Okumura |
| Institution: | 1. Division of Rheumatology Department of Internal Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113, Tokyo, (Japan) 2. Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan 3. Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan |
| Abstract: | The IgG subclasses of immunoglobulin for intravenous injection (IVIg) were investigated after various different types of treatment. The level of IgG2 was relatively low in preparations treated with pepsin, but by changing the clone producing anti-IgG2 antibody, the level approached that of normal human serum. Though undetectable in sulfonated immunoglobulin preparations, IgG3 was detected after reoxidation. When determining the IgG subclasses of IVIg, it must be kept in mind that the apparent value may subsequently become lower due to the depressed reaction of the antibody. |
| Keywords: | IgG subclasses Immunoglobulin preparations Antibody depressed reaction Ig intravenous use |
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