甲基转移酶样蛋白家族的分子作用机制及在胃癌中的研究进展

甲基转移酶样蛋白(methyltransferase-like proteins,METTL)是一个大蛋白家族的一部分,其特征是存在s-腺苷甲硫氨酸(s-adenosylmethionine,SAM)的结合域,SAM是甲基化反应的共同底物.尽管这个蛋白家族的成员被显示或预测为RNA、DNA或蛋白质的甲基转移酶,但大多数甲基转移酶的特征仍然很差,识别这些潜在酶起作用的复合物有助于了解它们的功能和底物特异性.METTL蛋白家族与胃癌(gastric cancer,GC)的发生发展有密切作用,明确其与GC的关系与GC的诊断治疗及预后有着十分重要的作用.本研究是对METTL蛋白家族的作用机制及与GC的关系一次系统和全面的综述,以期为进一步研究这些潜在的新型甲基转移酶和GC的诊治提供重要的资源.

Molecular mechanism of methyltransferase-like protein family:Relationship with gastric cancer

Methyltransferase-like proteins(METTL)are part of a large protein family,which is characterized by the presence of an S-adenosylmethionine(SAM;a common substrate for methylation reactions)binding domain.Although members of this protein family have been shown or predicted as methyltransferases of RNA,DNA,or proteins,most methyltransferases are still poorly characterized.Identifying the complexes where these potential enzymes work can help to understand their function and substrate specificity.The METTL protein family is closely related to the occurrence and development of gastric cancer(GC),and its relationship with GC is of great importance in the diagnosis,treatment,and prognosis of GC.Here we give a systematic and comprehensive review of the mechanism of METTL protein family and its relationship with GC,with an aim to provide important resources for further research on these potential new methyltransferases and the diagnosis and treatment of GC.