MicroRNA与心房颤动关系的研究进展

心房颤动是最常见的持续性心律失常,并有较高的发病率和死亡率。其流行率预计在未来几年会进一步增加。尽管在过去十年中出现了心房颤动病理生理学的新分子概念,但目前可用的治疗方法仍存在主要局限性,包括效果差和严重的副作用,如心室恶性心律失常等。心房电重构、结构重构和自主神经重构是心房颤动的发病基础,但驱动这种重构的确切机制仍不完全清楚。MicroRNA代表大量小非编码RNA的亚组,降解或抑制其靶m RNA的翻译,从而调节基因表达并在广泛的生物学过程中起重要作用。临床上,越来越多的证据表明micro RNA在心血管疾病的发生发展中发挥关键作用。

The Relationship Between MicroRNA and Atrial Fibrillation

Atrial fibrillation is the most common persistent arrhythmia with high morbidity and mortality. Its prevalence is expected to increase further in the coming years. Although the new molecular concepts of atrial fibrillation pathophysiology have emerged during the last decade,the currently available therapeutic approaches have still major limitations including poor efficacy and serious side effects,such as malignant arrhythmias in the ventricle. Atrial electrical remodeling, structural remodeling and autonomic nerve remodeling are the pathogenesis of atrial fibrillation,but the exact mechanism driving this remodeling is still not fully understood. MicroRNAs represent a subgroup of small non-coding RNAs that degrade or inhibit the translation of their target m RNA,thereby regulating gene expression and playing an important role in a wide range of biological processes. Clinically,there is increasing evidence that micro RNAs play a key role in the development of cardiovascular disease.